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Intersection: A Journal at the Intersection of Assessment and LearningAssessment, evaluation, and research in higher education serve as a means to evaluate and document evidence of educational effectiveness. However, many existing approaches to assessment and evaluation lack rigor in their methodological design, responsiveness to changing student needs, and accessibility to researchers and practitioners with varying ...
Jordan Spencer, Christa E. Winkler
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Introduction: High Needs Schools - Preparing Teachers for Today's World
Occasional Paper Series, 2016 The subject of this Occasional Paper is the preparation of teachers for schools that—lacking sufficient resources, effective leadership, or vocal advocates—are failing to educate their students by any reasonable measures.
Jonathan Silin
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Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
International Journal of Aviation, Aeronautics, and Aerospace, 2016 Each new generation entering the workforce follows a unique path preparing them for success in their respective industry. A myriad of factors influence this transitional process including advancements in technology, economic and cultural factors as well ...
Nicholas D Wilson, Shayne A Daku
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Ways of Caring: How Relative Caregivers Support Children and Parents
Occasional Paper Series, 2017 Reports on a subset of findings from a study that explored the support roles of African American child care providers in poor Chicago neighborhoods. Based on ten in-depth interviews with relative caregivers, Bromer discusses five themes: caregiver's ...
Juliet Bromer
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Designing evaluation and research into educational initiatives: The global perspectives program [PDF]
, 2012 We describe the planning for evaluation research using a curriculum initiative project as a case study. The project was to design a generic Global Perspectives (GP) learning program to embed in first year units of study offered by the Faculty of Health ...
Phillips, R. +3 more
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source