Results 81 to 90 of about 368,821 (303)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

On the Impact Assessment of ACIAR (Australian Centre for International Agricultural Research) Projects [PDF]

open access: yes
The current ACIAR (Australian Centre for International Agricultural Research) guidelines for impact assessment of agricultural development projects see impact assessment as being useful for both accountability to stakeholders and as a learning tool to ...
Farquharson, Robert J.   +2 more
core  

Do schools narrow the socioeconomic digital divide? Meta-analytic evidence from ICILS 2023

open access: yesLarge-scale Assessments in Education
Second-level digital divides, often studied as the association between socioeconomic status (SES) and digital competence, remain a central concern in digital educational research.
Tamara Kastorff   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Authentic assessment and performance assessment : A conceptual analysis of the literature

open access: yes, 2008
 Performance assessment and authentic assessment are recurrent terms in the literature on education and educational research. They have both been given a number of different meanings and unclear definitions and are in some publications not defined at all.
Palm, Torulf,
core  

How can I use Irish language e-portfolios in the assessment for learning approach in my primary classroom? [PDF]

open access: yes, 2009
This paper investigates the process of assessment for learning (AfL) in the primary school Irish language classroom. Electronic portfolios (e-portfolios) are used as a tool in assessment for learning with eight of my second class pupils in an urban ...
Clerkin, Martina
core   +2 more sources

Editorial: Online assessment for humans: advancements, challenges and futures for digital assessment

open access: yesFrontiers in Education, 2023
Elizabeth Archer   +4 more
doaj   +1 more source

Public Schools, and Health Care: A Strategy to Promote Social Inclusion

open access: yesOccasional Paper Series, 2017
Sladkova, Viladrich, and Freudenberg refer to “social inclusion” as the process through which the newly arrived find their voice in an already complex, cacophonous society.
Jana Sladkova   +2 more
doaj   +1 more source

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