Results 101 to 110 of about 3,845,941 (373)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Educational Leadership for Results or for Learning? Contrasting Directions in Times of Transition [PDF]

Educational leadership, like educational systems and schooling, is steered by the national political, professional and social contexts in which it occurs.
David Oldroyd
core  

Portrait methodology and educational leadership : putting the person first [PDF]

, 2009
This article describes a variant on a methodological approach which provides ways of developing educational leaders' understandings of themselves and their situation through the production of individually written 'portraits' which focus upon the ...
Bottery, Michael, Ngai, Siu Keung George, Wong, Ping Man, Wright, Nigel   +3 more
core  

Judging the impact of leadership-development activities on school practice [PDF]

, 2003
The nature and effectiveness of professional-development activities should be judged in a way that takes account of both the achievement of intended outcomes and the unintended consequences that may result.
Alan Marr, Baumard P., Bennett N., Bennett N., Bennett N., Bryman A., Cave E., Conger J., Duignan P., Eraut M., Fiedler F., Goddard J., Guskey T., House R., Joyce B., Lawrence I., Mintzberg H., Morley I., Nigel Bennett, Ogawa R., Ogawa R., Ryle G., Sternberg R., Wallace M., Wenger E., Woodhead C.   +25 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

System leadership for school improvement: A developing concept and set of practices [PDF]

, 2016
System'leadership'is'a'developing'concept'and'practice'increasingly'seen'as'a' tool'for' school' improvement,' as' policy'makers' switch'from'traditional'top?down' reform' to' professional' models' of' schools' working' collaboratively.' System ...
Dimmock, Clive
core  

Kepemimpinan Visioner Dalam Perspektif Islam [PDF]

, 2017
The Visionary Leadership is its significant role to improve the institution is including in educational institution. The Visionary Leadership is one of leadership is considered to increase the educational quality today.
BUDIMAN, H. (HARIS)
core   +3 more sources

Exploring teen well-being and social media use during the pandemic summer of 2020

International Journal of Adolescence and Youth
Social media has become a ubiquitous activity for teens in the United States with most going online daily. Legitimate concerns about teen well-being and mental health have often pointed to social media as a negative influence, yet prior research finds ...
Stacey A. Rutledge, Stephen Bunn, Michal Paul, Vanessa Dennen, Toby Park-Gaghan   +4 more
doaj   +1 more source

EXPLORING THE PREVALENCE OF RACISM IN FORMER MODEL C SCHOOLS IN SOUTH AFRICA [PDF]

Social Sciences and Education Research Review
The purpose of the study was to investigate the prevalence of racism in former Model C schools in South Africa, with a specific focus on the perspective of social justice.
Saltiel K. C. MATABOGE, Vimbi P. MAHLANGU   +1 more
doaj   +1 more source