Results 51 to 60 of about 1,310,505 (277)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Advancing Understanding of the Complexities of Niceness in Educational Leadership: Unpacking Contexts, Complicity, and the Harms of Niceness

Education Sciences
Niceness is deeply woven into the fabric of American educational institutions [...]
Cynthia D. Villarreal, Lauren R. Contreras, Angelina E. Castagno   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Responding to Racism in the Academy: Black Women Professors Engaging in Public Discourse

Social Sciences
Perspectives on race and gender from Black women professors in higher education today are shaped by their lived experiences navigating both systemic racism and sexism within academia. These perspectives often reflect a unique intersectional understanding
Kelsey Bogard, Ruqayyah Perkins-Williams, Mary Howard-Hamilton   +2 more
doaj   +1 more source

Leveraging Information and Communication Technologies to Enhance Parental Involvement in South Africa [PDF]

Social Sciences and Education Research Review
The potential of information and communication technologies (ICTs) to improve teaching and learning is gaining traction in South African schools. Previously, economic, social and geographical factors constrained parental involvement and participation in ...
Thomas Hlongwane, Mapheleba Lekhetho
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Strategies to address learner aggression in rural South African secondary schools

Koers : Bulletin for Christian Scholarship, 2013
Managing learner aggression in the school system is central to learners’ academic performance and holistic development. In order to manage learner aggression, it is important to understand the contributory factors and the forms of learner aggression ...
Gunam D. Singh, Gertruida M. Steyn
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Integrating ICT in Mathematics Pedagogy: A Contextual Analysis of Pre-Tertiary Teachers’ Practices in Ghana

Human Behavior and Emerging Technologies
In spite of the prioritization of technology in educational institutions, its integration in mathematics teachers’ instructional practices at the pre-tertiary level remains low.
Gabriel Assamah, Amadu Sualisu, Francis Kwesi Nsakwa Gabriel-Wettey, Richard Kyere Asomah, Usman Kojo Abonyi, Doreen Ahwireng   +5 more
doaj   +1 more source