Results 61 to 70 of about 154,155 (340)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Mediapractices in the digital environment: Educational context

Управление культурой
Introduction. In the context of the evolving digital environment, media practices hold a significant place. These practices involve the use of information and communication tools for creating and consuming specific content, as well as for establishing ...
Irina Ya. Murzina, Natal’ya A. Simbirtseva   +1 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

MEDIA PUBLIKASI HUMAS DALAM PENDIDIKAN

Al-Tanzim: Jurnal Manajemen Pendidikan Islam, 2018
The effort to build good relations with the media is one way to make the institution's image better. Media use activities are carried out to influence the public to achieve organizational goals.
Hannah Mahfuzhah, Anshari Anshari
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Genre Features of the Educational Media Discourse in the Context of Information Ecology and Cyber Security

RUDN Journal of Language Studies, Semiotics and Semantics
In the 21st century, the interdisciplinary research interest is increasingly aroused by the linguistic problem of realizing educational discourse, especially in the media space. Information ecology and cyber security make it possible to form the skill of
Olga V. Sergeeva, Marina R. Zheltukhina, Elena B. Ponomarenko   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Developing Educational Software: a professional tool perspective [PDF]

, 2000
The selection, and use of educational software and its impact in schools are still controversial issues. In this paper we present an alternative conceptualisation of educational software based on considering the software as an instrument for teachers ...
Preston, Christina, Mellar, Harvey, Hinostroza, Juan Enrique, Rehbein, L   +3 more
core  

Die Planung von Lehr-Lern-Einheiten mit digitalen Medien: Konzepte und Befunde

Zeitschrift für Weiterbildungsforschung - Report, 2016
Zusammenfassung Die Planung von Lehr-Lern-Einheiten gehört zu den Kernaufgaben von Lehrenden in der Erwachsenen- und Weiterbildung. Sie stellt eine regelmäßig wiederkehrende Anforderung dar, die es erfordert, fallbezogene Entscheidungen über die Ziele ...
Josef Schrader, Sabine Schöb
doaj   +1 more source