Results 71 to 80 of about 154,155 (340)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Conceptual and socio-cognitive support for collaborative learning in videoconferencing environments [PDF]

open access: yes, 2006
Studies have shown that videoconferences are an effective medium for facilitating communication between parties who are separated by distance. Furthermore, studies reveal that videoconferences are effective when used for distance learning, particularly ...
Mandl, Heinz   +5 more
core   +1 more source

الإعلام التربوي بالمرحلة الجامعية ودوره في التوعية بمخاطر التطرف الفکري [PDF]

open access: yesالمجلة العلمیة لبحوث العلاقات العامة والإعلان, 2019
هدفت الدراسة إلى التعرف على دور الإعلام التربوي بالمرحلة الجامعية في التوعية بمخاطر التطرف الفکري، مُتَخِذةً من جامعة الحدود الشمالية بعرعر بالمملکة العربية السعودية نموذجاً للدراسة، وتعد هذه الدراسة وصفية تحليلية، حيث اعتمدت على استخدام منهج المسح ...
هشام سعد زغلول
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Educational Media: International Perspectives

open access: yes
This edited volume explores how teaching and learning activities impact knowledge transmission and acquisition through educational media. The three spotlighted areas are discourses and representations, social networks and teacher resources, and school ...

core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Rich environments for active learning: a definition [PDF]

open access: yes, 1995
Rich Environments for Active Learning, or REALs, are comprehensive instructional systems that evolve from and are consistent with constructivist philosophies and theories.
Grabinger, R. Scott   +4 more
core   +1 more source

ممارسة أنشطة الإعلام المدرسى وعلاقتها بتنمية مهارات التواصل التعليمى لدى تلاميذ المرحلة الإعدادية [PDF]

open access: yesالمجلة العلمية لكلية التربية النوعية - جامعة المنوفية, 2014
ملخص البحث هدف البحث إلى التعرف على العلاقة بين ممارسة تلاميذ المرحلة الإعدادية لأنشطة الإعلام المدرسى وتنمية مهارات الاتصال والتواصل التعليمى لديهم وذلک من خلال التعرف على مدى وجود فروق بين التلاميذ الممارسين لأنشطة الإعلام المدرسى والتلاميذ غير ...
هشام رشدى خيرالله
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Designing for interaction [PDF]

open access: yes, 2004
At present, the design of computer-supported group-based learning (CS)GBL) is often based on subjective decisions regarding tasks, pedagogy and technology, or concepts such as ‘cooperative learning’ and ‘collaborative learning’.
Martens, RL   +11 more
core   +1 more source

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