Results 51 to 60 of about 945,387 (307)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Educational possibilities of the role information modeling

open access: yesRUDN Journal of Informatization in Education, 2011
В статье анализируется ролевое информационное моделирование, которое позволяет разрабатывать бифункциональные информационные модели с доминирующими функциями.
S V Junov, E V Feshina
doaj  

FEATURES OF USING EDUCATIONAL DIALOGUE IN THE STUDY OF A FOREIGN LANGUAGE

open access: yesОсвітній вимір, 2004
The article deals with the possibilities of educational dialogue while learning the English Language by senior pupils. Special attention is paid to the usage of the educational dialogue during the lessons in home reading.
H.M. Pedosyuk
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

WORKING WITH/IN THE TENSIONS: EDUCATIONAL TECHNOLOGY AS FEMINIZED CRAFTWORK

open access: yesDigital Culture & Education, 2022
This paper argues that the literature of feminized craftwork offers insights for understanding educational technology as a tension-negotiating practice through which we might learn to see and experience alternate possibilities for the field of ...
Tanya Elias
doaj  

Trayectorias: a new model for online task-based learning [PDF]

open access: yes, 2004
This paper discusses a framework for designing online tasks that capitalizes on the possibilities that the Internet and the Web offer for language learning.
Mardomingo, R., Ros i Sole, C.
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Magnetic and multistable: reinterpreting the affordances of educational technology

open access: yesInternational Journal of Educational Technology in Higher Education, 2018
The concept of affordances has become a popular analytical tool in educational technology. The present article, however, argues that the current understanding of affordances does not adequately address the use of educational technology and instead ...
Jesper Aagaard
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

DESIGN OF MULTIPURPOSE ELECTRONIC EDUCATIONAL RESOURCES MEANS OF INFORMATION AND COMMUNICATION TECHNOLOGIES

open access: yesВестник Северо-Кавказского федерального университета, 2022
In article systematized possibilities of information and communication technologies for design of structure and the maintenance of multipurpose electronic educational resources.
Natalya A. Poddubnaya
doaj  

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