Results 51 to 60 of about 427,659 (248)

Implementation and Actualization of Human Resource Development Programs to Improve Teacher Professionalism in Junior High Schools in the Hinterland Area of Batam

Jurnal Inovasi Pendidikan dan Sains
This study explores the implementation and actualization of human resource development (HRD) programs aimed at enhancing teacher professionalism in junior high schools within Batam’s hinterland.
Pusvariauwaty Pusvariauwaty, Tubagus Pamungkas, Alpino Susanto   +2 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Development of an Interactive E-book based on the ARCS Model to Improve Students' Arabic Writing Skills

Jurnal Al Bayan: Jurnal Jurusan Pendidikan Bahasa Arab
Arabic writing skill is the most difficult skill where many students are weak in this skill and the available teaching materials are less engaging. Therefore development of teaching materials based on the ARCS model was needed to help improve students ...
Indaha Nur Wahyuni, Sariyatun Sariyatun, Moh. Muchtarom, Hanan Alhakimi   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Assessing academic anxiety in d/Deaf, DeafBlind, and hard of hearing individuals

Frontiers in Psychology
Students encounter many challenges to academic success. Whereas some students thrive in stressful environments, other students falter. Some students also encounter social and emotional factors that might detract from academic achievement, including ...
Rachel Gabriella Pizzie, Christina Eun-Young Kim, Rachel Marie Sortino, Rachel Inghram   +3 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Implementation of the Independent Learning Curriculum in Improving Student Learning Outcomes

Jurnal Inovasi Pendidikan dan Sains
This study aims to describe and analyze the implementation of the Independent Learning Curriculum with a focus on the development of the school operational curriculum, the use of teaching tools, the Pancasila Student Profile (P5) project, and learning ...
Lailawati Lailawati, Najmuddin Najmuddin, Siraj Siraj   +2 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

EXPLORING THE INTERPLAY OF SELF-ESTEEM, GRATITUDE, AND SUBJECTIVE WELL-BEING AMONG MUSLIM UNIVERSITY STUDENTS IN STATE ISLAMIC UNIVERSITY OF NORTH SUMATRA INDONESIA

Journal of Contemporary Islam and Muslim Societies
: This study examines the relationship between self-esteem, gratitude, and the subjective well-being of students at the Faculty of Tarbiyah and Teacher Training (FITK), State Islamic University of North Sumatra.
Syauqina Batubara, Suryani Hardjo, Salamiah Sari Dewi   +2 more
doaj   +1 more source