Results 61 to 70 of about 3,241,108 (302)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Revue Internationale d’Éducation de Sèvres, 2011 A number of African countries have previously entrusted teachers with the immense responsibility of supporting curriculum reform. Very few African institutions, including universities, offer training in curriculum development, even though funding is ...
Paul Mushi
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Creating Reusable Educational Components: Lessons from DLESE [PDF]
, 2002 Reuse of educational materials is integral to many educator tasks, from designing a course to preparing for a lab or class. This article describes a study on the reuse of educational materials in the context of the Digital Library for Earth System ...
Holly Devaul +2 more
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Education and life satisfaction: perception or reality? [PDF]
Using data from the Gallup World Poll, this paper analyze the way in which perceptions on thequality of education affect wellbeing. In addition, we explore if educational quality perceptions aredetermined by objective educational outputs, such as ...
Carolina Mejía +2 more
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Promoting Students’ Sense of Coherence in Medical Education Using Transformative Learning Activities
Advances in Medical Education and Practice, 2020 Ida Katrine Riksaasen Hatlevik,1 Sylvi Stenersen Hovdenak1,2 1Department of Teacher Education and School Research, Faculty of Educational Sciences, University of Oslo, Oslo 0317, Norway; 2Faculty of Health Sciences, University of Tromsø - The ...
Hatlevik IKR, Hovdenak SS
doaj
Repeated evaluations of the quality of clinical teaching by residents
Perspectives on Medical Education, 2013 Many studies report on the validation of instruments for facilitating feedback to clinical supervisors. There is mixed evidence whether evaluations lead to more effective teaching and higher ratings.
Cornelia R. M. G. Fluit +5 more
doaj +1 more source