Results 31 to 40 of about 316,904 (267)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The frequency and acceptance of educational technology as a learning tool among faculty members

Journal of Medical Education Development
Background & Objective: Educational technologies improve instruction and make learning easier. They have several advantages, such as encouraging active learning, raising motivation, and improving the standard of instruction. This study aimed to determine
Farnaz Shavandi, Hossein Emad Momtaz, Nastaran Moradi, Zahra Cheraghi, Masoumeh Seidi   +4 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

'Everyone is just so furiously typing': supporting student choices around digital notetaking in university lectures

Journal of Learning Development in Higher Education
University of Bristol students have indicated that 65% of them take notes digitally. As learning developers, how do we support students to take fit-for-purpose digital notes against a background of changing technology?
Rebecca Arden, Simon Gamble
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Observation mediated by computer - a professional report

Online Brazilian Journal of Nursing, 2006
New observation forms are being studied as form of enlarging the potential of this data collection technique. The objective was to describe the use of observation mediated by computer as a resource of observation instrument.
Marcos Venícios de Oliveira Lopes, Viviane Martins da Silva, Thelma Leite de Araujo   +2 more
doaj  

Educational technology and the traditional lecture

Research in Learning Technology, 1994
I was recently invited to give a lecture at the opening of a new high-technology lecture theatre at Leeds Metropolitan University. It is one of the best examples of its kind I have seen.
Gabriel Jacobs
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Validation of educational booklet: an educational technology in dengue prevention

Revista Brasileira de Enfermagem
Objective: to validate a booklet on dengue prevention in order to make it an educational technology to be used with the population. Method: methodological study, carried out with two groups of judges specialized in health and other areas.
Camila Fernandes Wild, Elisabeta Albertina Nietsche, Cléton Salbego, Elizabeth Teixeira, Natalia Barrionuevo Favero   +4 more
doaj   +1 more source