Results 41 to 50 of about 321,487 (265)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Educational Technology / Opvoedkundige Tegnologie: Instructional Media

Scientia Militaria, 2012
The universal question so often asked by instructors is how does one choose which medium to use for different parts of a course. The questioner usually expects to be referred to a beautifully constructed algorithm or a carefully balanced analysis of ...
N.C. Parkins
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Observation mediated by computer - a professional report

Online Brazilian Journal of Nursing, 2006
New observation forms are being studied as form of enlarging the potential of this data collection technique. The objective was to describe the use of observation mediated by computer as a resource of observation instrument.
Marcos Venícios de Oliveira Lopes, Viviane Martins da Silva, Thelma Leite de Araujo   +2 more
doaj  

The frequency and acceptance of educational technology as a learning tool among faculty members

Journal of Medical Education Development
Background & Objective: Educational technologies improve instruction and make learning easier. They have several advantages, such as encouraging active learning, raising motivation, and improving the standard of instruction. This study aimed to determine
Farnaz Shavandi, Hossein Emad Momtaz, Nastaran Moradi, Zahra Cheraghi, Masoumeh Seidi   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The Technology Imperative in Education [PDF]

, 2001
The technological imperative can be an insidious master. It can become the central goal of our endeavors rather than just one way through which goals can be reached. This misdirection can have very real and lasting consequences. For this reason, the basis for action in terms of information systems development and implementation must be kept visible to ...
William T. Bonner, Abhijit Gopal
openaire   +1 more source

'Everyone is just so furiously typing': supporting student choices around digital notetaking in university lectures

Journal of Learning Development in Higher Education
University of Bristol students have indicated that 65% of them take notes digitally. As learning developers, how do we support students to take fit-for-purpose digital notes against a background of changing technology?
Rebecca Arden, Simon Gamble
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source