Results 51 to 60 of about 518,624 (266)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Fracture and Structural Integrity, 2019 The objective of the study is to introduce an experimental uncertainty budget process for concrete compressive strength test, based on a protocol that incorporates effects of multiple factors significant for the measurement result.
Stamatia Gavela +4 more
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
COMPUTER SECURITY AND SECURITY TECHNOLOGIES [PDF]
Journal of Process Management and New Technologies, 2013 With the increasing development of computer and communications technology growth and increasing needs and development of information systems security. The problem of security must be approached with greater caution.
Lazar Stošić, Dragan Veličković
doaj
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Between the University and the Monastery: The Ethiopian Church and the Transformation of Knowledge
Kulturní StudiaThis article examines the transformations of the Ethiopian Orthodox educational system ʾAbənnat Təmhərt in the context of modernity and digital culture. It argues that the Ethiopian Orthodox Church constitutes a unique case in which education, faith, and
Asrat Tsegaw, Tilahun Tsegaye
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Journal of Curriculum Studies, 2019 本書對於全球化過程中教育改革和政策的借用相關議題提供一個基礎的認識。全球化對於教育政策有深遠的影響，尤其是對發展中國家之教育。全球化的影響已不僅止於政治層面，甚至已深入到生活層面。猶記筆者公費留學剛到美國唸書時，就已選修著名教授M. Peters和F. Rizvi合開的全球化課程，當時兩位教授於課堂上常會彼此互動論辯，激盪出許多火花，也讓學生對於全球化有更多層面的觀點與思維。課堂中的學生來自世界各地，全球化議題的討論更顯得如此貼近實際生活，課堂之餘，學生的交流也確實感受到全球化和在地化並存融合的氛圍 ...
劉子彰 Tze-Changm Liu
doaj +1 more source