Results 91 to 100 of about 4,692,305 (307)

Quasi-Experimental Estimates of the Effect of Class Size on Achievement in Norway [PDF]

open access: yes
Using a comprehensive administrative database we exploit independent quasi-experimental methods to estimate the effect of class size on student achievement in Norway.
Leuven, Edwin   +2 more
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Are biologically meaningful effect sizes a factor in study design? A systematic review of translational chronic variable stress studies

open access: yesExperimental Physiology
The design of in vivo studies using laboratory animals is normally guided by the 3Rs: Replacement, Reduction and Refinement. The concept of Reduction is particularly important in the context of estimating sample size; the selected sample size should ...
Crispin Jordan   +2 more
doaj   +1 more source

HIV-related stigma and associated factors: a systematic review and meta-analysis

open access: yesFrontiers in Public Health
BackgroundIt has been recognized that HIV-related stigma hinders efforts in testing, treatment, and prevention. In this systematic review, we aimed to summarize available findings on the association between HIV-related stigma and age, social support ...
Zelalem G. Dessie   +2 more
doaj   +1 more source

Measuring Distribution Similarities Between Samples: A Distribution-Free Overlapping Index

open access: yesFrontiers in Psychology, 2019
Every day cognitive and experimental researchers attempt to find evidence in support of their hypotheses in terms of statistical differences or similarities among groups.
Massimiliano Pastore, Antonio Calcagnì
doaj   +1 more source

Size effect in micro-scale cantilever beam bending [PDF]

open access: yes, 2011
When the thickness of metallic cantilever beams reduces to the order of micron, a strong size effect of mechanical behavior has been found. In order to explain the size effect in a micro-cantilever beam, the couple-stress theory (Fleck and Hutchinson, J ...
Chen, SH (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Size Effect and Geometrical Effect of Polycrystals and Thin Film/Substrate System in Micro-indentation Test [PDF]

open access: yes, 2002
Micro-indentation test at scales on the order of sub-micron has shown that the measured hardness increases strongly with decreasing indent depth or indent size, which is frequently referred to as the size effect.
Wang XZ(王学峥)   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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