Results 51 to 60 of about 706,935 (292)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Alteration in the Functional Organization of the Default Mode Network Following Closed Non-severe Traumatic Brain Injury

Frontiers in Neuroscience, 2022
The debilitating effect of traumatic brain injury (TBI) extends years after the initial injury and hampers the recovery process and quality of life.
Muhammad Riddha Abdul Rahman, Muhammad Riddha Abdul Rahman, Muhammad Riddha Abdul Rahman, Aini Ismafairus Abd Hamid, Aini Ismafairus Abd Hamid, Aini Ismafairus Abd Hamid, Nor Azila Noh, Hazim Omar, Hazim Omar, Hazim Omar, Wen Jia Chai, Wen Jia Chai, Zamzuri Idris, Zamzuri Idris, Zamzuri Idris, Asma Hayati Ahmad, Diana Noma Fitzrol, Diana Noma Fitzrol, Diana Noma Fitzrol, Ab. Rahman Izaini Ghani Ab. Ghani, Ab. Rahman Izaini Ghani Ab. Ghani, Ab. Rahman Izaini Ghani Ab. Ghani, Wan Nor Azlen Wan Mohamad, Wan Nor Azlen Wan Mohamad, Wan Nor Azlen Wan Mohamad, Mohamed Faiz Mohamed Mustafar, Mohamed Faiz Mohamed Mustafar, Mohamed Faiz Mohamed Mustafar, Muhammad Hafiz Hanafi, Muhammad Hafiz Hanafi, Muhammad Hafiz Hanafi, Mohamed Faruque Reza, Mohamed Faruque Reza, Mohamed Faruque Reza, Hafidah Umar, Hafidah Umar, Hafidah Umar, Mohd Faizal Mohd Zulkifly, Mohd Faizal Mohd Zulkifly, Mohd Faizal Mohd Zulkifly, Song Yee Ang, Song Yee Ang, Song Yee Ang, Zaitun Zakaria, Zaitun Zakaria, Zaitun Zakaria, Kamarul Imran Musa, Azizah Othman, Zunaina Embong, Nur Asma Sapiai, Regunath Kandasamy, Haidi Ibrahim, Mohd Zaid Abdullah, Kannapha Amaruchkul, Pedro Valdes-Sosa, Pedro Valdes-Sosa, Maria Luisa-Bringas, Maria Luisa-Bringas, Bharat Biswal, Jitkomut Songsiri, Hamwira Sakti Yaacob, Putra Sumari, Paramjit Singh Jamir Singh, Azlinda Azman, Jafri Malin Abdullah, Jafri Malin Abdullah, Jafri Malin Abdullah   +66 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Effective Connectivity Modeling for fMRI: Six Issues and Possible Solutions Using Linear Dynamic Systems

Frontiers in Systems Neuroscience, 2012
Analysis of directionally specific or causal interactions between regions in functional magnetic resonance imaging (fMRI) data has proliferated. Here we identify six issues with existing effective connectivity methods that need addressed.
Jason Fitzgerald Smith, Ajay S Pillai, Kewei eChen, Kewei eChen, Kewei eChen, Barry eHorwitz   +5 more
doaj   +1 more source

Classification of EEG-Based Brain Connectivity Networks in Schizophrenia Using a Multi-Domain Connectome Convolutional Neural Network

, 2019
We exploit altered patterns in brain functional connectivity as features for automatic discriminative analysis of neuropsychiatric patients. Deep learning methods have been introduced to functional network classification only very recently for fMRI, and ...
Hussain, Hadri, Noman, Fuad Mohammed, Ombao, Hernando, Phang, Chun-Ren, Ting, Chee-Ming   +4 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Comparing effective and functional connectivity

Scientific Reports
Information processing in the brain is thought to result from the coordination of large-scale neuronal activity. However, this activity occurs within fine neural circuits.
Shigeru Shinomoto, Yasuhiro Tsubo
doaj   +1 more source

Dysfunction in the Interaction of Information Between and Within the Bilateral Primary Sensory Cortex

Frontiers in Aging Neuroscience, 2022
BackgroundInterhemispheric and intrahemispheric long-range synchronization and information communication are crucial features of functional integration between the bilateral hemispheres.
Xiang-Xin Xing, Xiang-Xin Xing, Xiang-Xin Xing, Zhen-Zhen Ma, Zhen-Zhen Ma, Jia-Jia Wu, Jia-Jia Wu, Jie Ma, Jie Ma, Yu-Jie Duan, Yu-Jie Duan, Xu-Yun Hua, Xu-Yun Hua, Mou-Xiong Zheng, Mou-Xiong Zheng, Jian-Guang Xu, Jian-Guang Xu   +16 more
doaj   +1 more source

Estimating Time-Varying Effective Connectivity in High-Dimensional fMRI Data Using Regime-Switching Factor Models

, 2017
Recent studies on analyzing dynamic brain connectivity rely on sliding-window analysis or time-varying coefficient models which are unable to capture both smooth and abrupt changes simultaneously. Emerging evidence suggests state-related changes in brain
Ombao, Hernando, Salleh, Sh-Hussain, Samdin, S. Balqis, Ting, Chee-Ming   +3 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source