Results 71 to 80 of about 6,293,610 (293)

Differential Patterns of Connectivity in Progressive Mild Cognitive Impairment

, 2012
It is now widely accepted that Alzheimer's disease is characterized by a functional disconnection between brain regions. The disease appears to begin up to decades prior to clinical diagnosis.
Aurtenetxe, Sara, Maestú, Fernando, del pozo, Francisco, Castellanos, Nazareth, Bajo, Ricardo, Garcia-Prieto, Juan, Cuesta, Pablo, Gil-Gregorio, Pedro, Pozo, Francisco del, Bajo Bretón, Ricardo, Maestu Unturbe, Fernando, Cuesta Prieto, Pablo, Gil Gregorio, Pedro, Castellanos, Nazareth P.   +13 more
core   +1 more source

Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa

NeuroImage: Clinical, 2014
Neuroimaging studies investigating the neural profile of anorexia nervosa (AN) have revealed a predominant imbalance between the reward and inhibition systems of the brain, which are also hallmark characteristics of the disorder. However, little is known
Stephanie Kullmann, Katrin E. Giel, Martin Teufel, Ansgar Thiel, Stephan Zipfel, Hubert Preissl   +5 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Presentation_1_State-Dependent Effective Connectivity in Resting-State fMRI.pdf

, 2021
The human brain at rest exhibits intrinsic dynamics transitioning among the multiple metastable states of the inter-regional functional connectivity. Accordingly, the demand for exploring the state-specific functional connectivity increases for a deeper ...
Jiyoung Kang (2113840), Hae-Jeong Park (460431), Chongwon Pae (7359305), Jinseok Eo (11592693), Sung Min Park (7304018), Junho Son (11611864)   +5 more
core   +1 more source

Abnormal synchrony and effective connectivity in patients with schizophrenia and auditory hallucinations

NeuroImage: Clinical, 2014
Auditory hallucinations (AH) are the most frequent positive symptoms in patients with schizophrenia. Hallucinations have been related to emotional processing disturbances, altered functional connectivity and effective connectivity deficits.
Maria de la Iglesia-Vaya, Maria José Escartí, Jose Molina-Mateo, Luis Martí-Bonmatí, Marien Gadea, Francisco Xavier Castellanos, Eduardo J. Aguilar García-Iturrospe, Montserrat Robles, Bharat B. Biswal, Julio Sanjuan   +9 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Scottish Government's Draft Budget 2018-19 : [Rural Economy and Connectivity Committee Comataidh Eaconomaidh Dùthchail is Cocheangailteachd] [PDF]

, 2018
In this report the Rural Economy and Connectivity Committee sets out its findings and recommendations on those aspects of the Scottish Government's Draft Budget 2018-19 which relates to its remit. Chapter 12 of the draft budget contains proposed spending
Rural Economy and Connectivity Committee
core   +2 more sources

Development of EEG connectivity from preschool to school-age children

Frontiers in Neuroscience
IntroductionMany studies have collected normative developmental EEG data to better understand brain function in early life and associated changes during both aging and pathology.
Jiannan Kang, Wenqin Mao, Juanmei Wu, Xinping Huang, Manuel F. Casanova, Estate M. Sokhadze, Estate M. Sokhadze, Xiaoli Li, Xinling Geng   +8 more
doaj   +1 more source

Changes in effective connectivity by propofol sedation.

PLoS ONE, 2013
Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent.
Francisco Gómez, Christophe Phillips, Andrea Soddu, Melanie Boly, Pierre Boveroux, Audrey Vanhaudenhuyse, Marie-Aurélie Bruno, Olivia Gosseries, Vincent Bonhomme, Steven Laureys, Quentin Noirhomme   +10 more
doaj   +1 more source