Results 121 to 130 of about 145,583 (300)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Drying and Rehydration of Sullius luteus Under Different Pretreatments: Kinetic Modeling, Rehydration, and Chromatic Changes

Applied Sciences
Edible mushrooms (Suillus luteus) represent valuable sources of nutrients and bioactive compounds that are sensitive to drying conditions. The objective of this study was to determine the drying time, kinetic model, effective diffusivity, activation ...
Alfredo Fernandez-Ayma, Víctor Justiniano Huamaní-Meléndez, Luis Fernando Pérez-Falcón, Franklin Lozano, Guadalupe Chaquilla-Quilca   +4 more
doaj   +1 more source

Characteristics of thin-layer infrared drying of green bean

Czech Journal of Food Sciences, 2015
The effect of infrared (IR) power on drying kinetics, rehydration, and colour of green beans was investigated. The drying experiments were carried out at 83, 104, 125, 146, 167, and 188 W.
Ibrahim DOYMAZ, Azmi Seyhun KIPCAK, Sabriye PISKIN   +2 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Molecular Dynamics Study of Self-Diffusion in Zr

, 2009
We employed a recently developed semi-empirical Zr potential to determine the diffusivities in the hcp and bcc Zr via molecular dynamics simulation. The point defect concentration was determined directly from MD simulation rather than from theoretical ...
I. Kaur, Mikhail I. Mendelev, P. G. Shewmon, Y. Mishin, Yuri Mishin   +4 more
core   +1 more source

Study of the relationships between structural parameters of disordered porous media and effective diffusivity by Kinetic Monte Carlo

Revista Facultad de Ingeniería Universidad de Antioquia, 2012
The effect of porosity and pore size on transport properties of hydrogen in a disordered porous medium is studied by kinetic Monte Carlo. The randomness of the pores in the medium, inscribed inside a simple cubic lattice, was corroborated by calculating
Alejandro Ramírez, John Jairo Castañeda, Elizabeth Pabón   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Prediction by Artificial Neural Networks (ANN) of the diffusivity, mass, moisture, volume and solids on osmotically dehydrated yacon (Smallantus sonchifolius)

Scientia Agropecuaria, 2012
The predictive ability of Artificial Neural Network (ANN) on the effect of the concentration (30, 40, 50 y 60 % w/w) and temperature (30, 40 y 50°C) of fructooligosaccharides solution, in the mass, moisture, volume and solids of osmodehydrated yacon ...
Julio Rojas Naccha, Víctor Vásquez Villalobos   +1 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source