Results 61 to 70 of about 98,864 (312)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Non-factorizable superamplitudes for massive N $$ \mathcal{N} $$ = 1 superstates

Journal of High Energy Physics
In this paper we study non-factorizable N $$ \mathcal{N} $$ = 1 superamplitudes for massive chiral superstates. We demonstrate how little group scaling and the supersymmetric Ward identities determine the form of non-factorizable massless superamplitudes,
Antonio Delgado, Adam Martin, Runqing Wang   +2 more
doaj   +1 more source

Whence the Effectiveness of Effective Field Theories? [PDF]

The British Journal for the Philosophy of Science, 2020
Effective Quantum Field Theories (EFTs) are effective insofar as they apply within a prescribed range of length-scales, but within that range they predict and describe with extremely high accuracy and precision. The effectiveness of EFTs is explained by identifying the features – the scaling behaviour of the parameters – which lead to effectiveness ...
openaire   +5 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

On the species scale, modular invariance and the gravitational EFT expansion

Journal of High Energy Physics
The concept of the species scale as the quantum gravity cut-off has been recently emphasised in the context of the Swampland program. Along these lines, we continue the quest for a precise understanding of its role within effective field theories of ...
A. Castellano, A. Herráez, L. E. Ibáñez   +2 more
doaj   +1 more source

Effective field theories for muonic hydrogen

EPJ Web of Conferences, 2017
Experimental measurements of muonic hydrogen bound states have recently started to take place and provide a powerful setting in which to study the properties of QCD.
Peset Clara
doaj   +1 more source

On effective field theories with celestial duals

Journal of High Energy Physics, 2022
We show that associativity of the tree-level OPE in a celestial CFT imposes constraints on the coupling constants of the corresponding bulk theory. These constraints are the same as those derived in [9] from the Jacobi identity of the algebra of soft ...
Lecheng Ren, Marcus Spradlin, Akshay Yelleshpur Srikant, Anastasia Volovich   +3 more
doaj   +1 more source

Effective field theory of cosmological perturbations [PDF]

Classical and Quantum Gravity, 2013
The effective field theory of cosmological perturbations stems from considering a cosmological background solution as a state displaying spontaneous breaking of time translations and (adiabatic) perturbations as the related Nambu-Goldstone modes. With this insight, one can systematically develop a theory for the cosmological perturbations during ...
Piazza, Federico, Vernizzi, Filippo
openaire   +5 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

T T ¯ $$ T\overline{T} $$ deformations in curved space from 4D Chern-Simons theory

Journal of High Energy Physics, 2022
In this paper, we shed new light onto T T ¯ $$ T\overline{T} $$ -deformations by engineering them on 2D surface defects, supporting chiral and antichiral CFT’s, in a 4D Chern-Simons bulk. This approach is motivated by various connections between T T ¯ $$
Victor Py
doaj   +1 more source