Results 131 to 140 of about 14,162,835 (267)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Effective reproduction number estimates for the MLE method and the Wallinga and Tuenis (WT) method.

, 2013
Effective reproduction number estimates for the MLE method and the Wallinga and Tuenis (WT) method.
Laura Forsberg White (55155), Marcello Pagano (55156)   +1 more
core   +1 more source

Mathematical model of tuberculosis with seasonality, detection, and treatment

Informatics in Medicine Unlocked
In this study, we use a modified SEIR compartmental model to investigate the transmission dynamics of tuberculosis as well as its detection and treatment.
Abdul Malek, Ashabul Hoque
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Unjustified Poisson assumptions lead to overconfident estimates of the effective reproductive number

Epidemiology and Infection
Abstract Time-varying effective reproductive numbers of infectious diseases are commonly estimated using renewal equation models. In the widely applied R package EpiEstim and various related tools, this approach is combined with a Poisson ...
Barbora Němcová, Isaac H. Goldstein, Jessalyn Sebastian, Volodymyr M. Minin, Johannes Bracher   +4 more
openaire   +3 more sources

Modeling and Characterizing the Growth of the Texas–New Mexico Measles Outbreak of 2025

Epidemiologia
Background: In late January 2025, a measles outbreak began in Gaines County, Texas, USA, and the outbreak extended to New Mexico. We used a variety of mathematical models to estimate the growth rate of the Texas–New Mexico measles outbreak of 2025 ...
Gilberto González-Parra, Annika Vestrand, Remy Mujynya   +2 more
doaj   +1 more source

Association of Ambient Temperature and Absolute Humidity with the Effective Reproduction Number of COVID-19 in Japan. [PDF]

Pathogens, 2023
Wagatsuma K.
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Effective reproduction number as a function of vaccination policy, coverage, and vaccine effectiveness.

, 2015
Color indicates effective reproduction number after vaccination. Columns A, B, and C use a contact matrix derived from all contacts recorded. Columns D, E, and F use a contact matrix derived from physical contacts only.
Naiyana Praditsitthikorn (180206), Ben S. Cooper (125462), Aronrag Meeyai (744963), Wantanee Kulpeng (744964), Surachai Kotirum (180216), Yot Teerawattananon (180232), Weerasak Putthasri (182131)   +6 more
core   +1 more source