Results 141 to 150 of about 1,411,342 (269)
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Mathematical model of tuberculosis with seasonality, detection, and treatment
Informatics in Medicine UnlockedIn this study, we use a modified SEIR compartmental model to investigate the transmission dynamics of tuberculosis as well as its detection and treatment.
Abdul Malek, Ashabul Hoque
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
[Effects of climate change on reproductive number of Chagas disease].
Revista medica de Chile, 2020 Reproductive number (R0)-maps estimate risk zones of vector-borne diseases and geographical distribution changes under climate change.To map R0 aiming to estimate the epidemiological risk of Chagas disease in Chile, its distribution and possible changes due to the global climate change.We used a relationship between R0 and entomological parameters of ...
Salvador, Ayala +4 more
openaire +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Modeling and Characterizing the Growth of the Texas–New Mexico Measles Outbreak of 2025
EpidemiologiaBackground: In late January 2025, a measles outbreak began in Gaines County, Texas, USA, and the outbreak extended to New Mexico. We used a variety of mathematical models to estimate the growth rate of the Texas–New Mexico measles outbreak of 2025 ...
Gilberto González-Parra +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Association of Ambient Temperature and Absolute Humidity with the Effective Reproduction Number of COVID-19 in Japan. [PDF]
Pathogens, 2023 Wagatsuma K.
europepmc +1 more source
Evolutionary Fitness in Variable Environments
, 2015 One essential ingredient of evolutionary theory is the concept of fitness as a measure for a species' success in its living conditions. Here, we quantify the effect of environmental fluctuations onto fitness by analytical calculations on a general ...
Melbinger, Anna, Vergassola, Massimo
core
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source