Results 121 to 130 of about 1,137,683 (250)

Study the effect of number of parturitions on the measurements of reproductive performance of dairy cows

Kufa Journal For Veterinary Medical Sciences, 2014
This study is conducted in Latifiya station for dairy cows in south east of Baghdad. Which have Holstein and Friesian and cross breed among them, from the first of April 2012 until the first of August 2014. Dystocia rate 69.81% recorded and also 26.8% retained placenta with 16% ovarian problem and 53% uterine problems for (386) cows.The cows of ...
Mohammad Y. Mahmood, Noorulden Y. Khudhair, Yaseen M. Rasheed   +2 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

[Effects of climate change on reproductive number of Chagas disease].

Revista medica de Chile, 2020
Reproductive number (R0)-maps estimate risk zones of vector-borne diseases and geographical distribution changes under climate change.To map R0 aiming to estimate the epidemiological risk of Chagas disease in Chile, its distribution and possible changes due to the global climate change.We used a relationship between R0 and entomological parameters of ...
Salvador, Ayala, Sergio, Alvarado, Dante, Cáceres, Inés, Zulantay, Mauricio, Canals   +4 more
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A poor-man’s approach to the effective reproduction number: the COVID-19 case [PDF]

, 2020
It is shown that estimates of the effective reproduction number R t for COVID-19 using standard packages such as E pi E stim can be reproduced very accurately using the ...
Menéndez J.
europepmc   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Etymologia: Reproduction Number

Emerging Infectious Diseases, 2023
Vijay Sharma, Rajnish Sharma, Balbir B. Singh   +2 more
doaj   +1 more source

Fractional-order dynamics of Lassa fever: a Caputo–Fabrizio modelling framework with real statistical data

Boundary Value Problems
In this work, a fractional-order mathematical model with hospitalization, developed and studied within the Caputo–Fabrizio framework, is used to capture the transmission dynamics of Lassa fever. Given the periodic occurrences of Lassa fever and the known
Azhar Iqbal Kashif Butt, Olumuyiwa James Peter, Ajay Kumar, Ghaniyyat Bolanle Balogun, Victor Aduragbemi Adekunle   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source