Results 101 to 110 of about 14,162,835 (267)

A poor-man’s approach to the effective reproduction number: the COVID-19 case [PDF]

, 2020
It is shown that estimates of the effective reproduction number R t for COVID-19 using standard packages such as E pi E stim can be reproduced very accurately using the ...
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Study the effect of number of parturitions on the measurements of reproductive performance of dairy cows

Kufa Journal For Veterinary Medical Sciences, 2014
This study is conducted in Latifiya station for dairy cows in south east of Baghdad. Which have Holstein and Friesian and cross breed among them, from the first of April 2012 until the first of August 2014. Dystocia rate 69.81% recorded and also 26.8% retained placenta with 16% ovarian problem and 53% uterine problems for (386) cows.The cows of ...
Mohammad Y. Mahmood, Noorulden Y. Khudhair, Yaseen M. Rasheed   +2 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Modelling the effect of vaccination on the dynamics of tuberculosis in an age-structured population

Proceedings of the Nigerian Society of Physical Sciences
Despite several efforts, Tuberculosis (TB) is still a global leading cause of death. This paper proposed an age-structured deterministic model governing the transmission dynamics and control of TB in the presence of vaccination integrated into the ...
Omowumi Fatimah Lawal, Afeez Abidemi
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Changing contact patterns in Newfoundland and Labrador, Canada in response to public health measures during the COVID-19 pandemic

Epidemics
The provincial government of Newfoundland and Labrador, Canada implemented a contact tracing program as part of a containment strategy during the COVID-19 pandemic.
Renny Doig, Amy Hurford, Suzette Spurrell, Andrea Morrissey, Liangliang Wang, Caroline Colijn   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The effect of population structure, plant size, herbivory and reproductive potential on effective population size in the temperate epiphytic orchid, Sarcochilus australis [PDF]

, 2013
Distribution of plant size and reproductive success is investigated in the temperate epiphytic orchid Sarcochilus australis (Lindl.) Rchb. f. at Kinglake National Park, Victoria, in south-eastern Australia, and applied to estimating the effective ...
Tremblay, Raymond L.
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