Results 81 to 90 of about 14,162,835 (267)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
The effective reproduction number under vaccination practice.
, 2013 Effective reproduction numbers for the observable model and the unobservable model are compared as a function of vaccine-induced reduction in symptomatic illness. To permit comparison, in the absence of vaccination practice, the epidemic threshold values
Keisuke Ejima (402068) +2 more
core +1 more source
Malaria JournalBackground Malaria remains a major global public health problem, particularly affecting children under 5 years of age and pregnant women in regions where temperatures are favorable for transmission.
Paul Kuya Robert +2 more
doaj +1 more source
Frontiers in Physics, 2020 Iran has been the country most affected by the outbreak of SARS-CoV-2 in the Middle East. With a relatively high case fatality ratio and limited testing capacity, the number of confirmed cases reported is suspected to suffer from significant ...
Meead Saberi +8 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Accuracy of estimation of effective reproduction number, R.
, 2015 Accuracy of estimation of effective reproduction number, R.
Adam J. Kucharski (124315) +1 more
core +1 more source
Assessing the Time Evolution of COVID-19 Effective Reproduction Number in Brazil
Anais da Academia Brasileira de CiênciasIn this paper, we use a Bayesian method to estimate the effective reproduction number ( R ( t )), in the context of monitoring the time evolution of the COVID-19 pandemic in Brazil at different geographic levels.
EDSON PORTO DA SILVA, ANTONIO M.N. LIMA
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source