Results 71 to 80 of about 1,411,342 (269)

Estimating effective reproductive number of COVID-19 in Shiraz, Iran

Archives of Advances in Biosciences, 2023
Introduction: COVID-19 is an infectious disease that first reported in Wuhan, China on 31 December 2019. After about 3 years later, it is still one of the main health problems all over the world. The goal of this study is to estimated reproductive number parameter to understand the speed and dynamic of the disease in Shiraz, Fars province of Iran ...
Taherian, Reza, Khodakarim, Soheila, Alavi Majd, Hamid, Alipour, Abbas   +3 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The role of asymptomatic carriers on the dynamics of a lymphatic filariasis model incorporating control strategies

Results in Control and Optimization
This study presents a mathematical model to investigate the patterns of transmission in lymphatic filariasis. The model considers chronic, acute, and asymptomatic individuals and integrates key control strategies.
Mussa A. Stephano, Maranya M. Mayengo, Jacob I. Irunde   +2 more
doaj   +1 more source

Epidemic Data Analysis of Three Variants of COVID-19 Spread in Indonesia

Jurnal Ilmu Komputer dan Informasi, 2022
Three variants of COVID-19 had been found in Indonesia. A control strategy may rely on the transmission rate of the variant. This study aims to investigate how the variants spread in Indonesia by computing a basic and effective reproduction number on the
Inna Syafarina, Taufiq Wirahman, Syam Budi Iryanto, Arnida Lailatul Latifah   +3 more
doaj   +1 more source

Elevated reproduction does not affect telomere dynamics and oxidative stress [PDF]

, 2016
: Oxidative stress and telomere dynamics are considered to be powerful biomarkers quantifying a potential trade-off between current reproduction and self-maintenance. Recent studies confirmed the negative impact of elevated reproduction on telomeres, but
Casasole, Giulia, Cichoń, Mariusz, Rutkowska, Joanna, Sudyka, Joanna   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Memory Rehabilitation Strategies in Nonsurgical Temporal Lobe Epilepsy: A Review [PDF]

, 2017
open8siPeople with temporal lobe epilepsy (TLE) who have not undergone epilepsy surgery often complain of memory deficits. Cognitive re- habilitation is employed as a remedial intervention in clinical settings, but research is limited and findings ...
Alderighi, Marzia, Bosco, Anna, Del Felice, Alessandra, Grisafi, Davide, Martinato, Matteo, Masiero, Stefano, Sander, Josemir W., Thompson, Pamela J.   +7 more
core   +2 more sources

Control of zootechnology leads to improved Cuttlefish (Sepia officinalis, L.) reproduction performance up to pre-industrial levels [PDF]

, 2020
Cephalopods are gaining momentum as an alternate group for aquaculture species diversification, not only because they are a good food source (highly appreciated in some worldwide markets) but they also have the potential to quickly reach a market size ...
Alves, Alexandra, Andrade, José Pedro, Balvet, Safia, Baptista Gonçalves, Rui, Capaz, Juan Carlos, Couto, Ana T., Frias, Paulo A., Hernández-Brooke, Daniel, Sykes, António   +8 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Estimation of R(t) based on illness onset data: An analysis of 1907–1908 smallpox epidemic in Tokyo

Epidemics, 2022
R(t), the actual average number of secondary cases per primary case at calendar time t, is epidemiologically useful in assessing transmission dynamics in a population with varying susceptibility levels. However, a technical limitation of existing methods
Ko Nakajo, Hiroshi Nishiura
doaj   +1 more source