Results 71 to 80 of about 14,162,835 (267)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Estimating the Reproduction Number of Ebola Virus (EBOV) During the 2014 Outbreak in West Africa [PDF]
, 2014 The 2014 Ebola virus (EBOV) outbreak in West Africa is the largest outbreak of the genus Ebolavirus to date. To better understand the spread of infection in the affected countries, it is crucial to know the number of secondary cases generated by an ...
Althaus, Christian L
core +2 more sources
Estimation of R(t) based on illness onset data: An analysis of 1907–1908 smallpox epidemic in Tokyo
Epidemics, 2022 R(t), the actual average number of secondary cases per primary case at calendar time t, is epidemiologically useful in assessing transmission dynamics in a population with varying susceptibility levels. However, a technical limitation of existing methods
Ko Nakajo, Hiroshi Nishiura
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Tropical Medicine and Health, 2005 To estimate the time-dependent transmission potential of primary pneumonic plague (PPP), we analyzed historical records from six outbreaks. Based on contact investigation information (source of infection information) of three outbreaks, we generalized the probability density function of the serial interval with a Gamma distribution using maximum ...
HIROSHI NISHIURA, MASAYUKI KAKEHASHI
openaire +3 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Centre for Effective Services: strategy 2012 – 2014 and beyond [PDF]
, 2012 The Centre for Effective Services (CES) was established in 2008 in the Republic of Ireland, and in 2010 in Northern Ireland. The overall remit of the centre was to provide technical and organisational ‘expertise’ to promote and support the application of
Centre for Effective Services
core
Estimating the effective reproduction number from wastewater (Rt): A methods comparison
EpidemicsBackground: The effective reproduction number (Rt) is a dynamic indicator of current disease spread risk. Wastewater measurements of viral concentrations are known to correlate with clinical measures of diseases and have been incorporated into methods ...
Dustin T. Hill +7 more
doaj +1 more source
Estimating the measles effective reproduction number in Australia from routine notification data
Bulletin of the World Health Organization, 2014 Objective To estimate the measles effective reproduction number (R) in Australia by modelling routinely collected notification data. Methods R was estimated for 2009–2011 by means of three methods, using data from Australia's National Notifiable ...
May Chiew +6 more
doaj +1 more source
Epidemiological Dynamics of SARS-CoV-2 Variants During Social Protests in Cali, Colombia
Frontiers in Medicine, 2022 BackgroundThe third wave of the global health crisis attributed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus reached Colombia in March 2021.
Luz H. Patiño +17 more
doaj +1 more source