Results 41 to 50 of about 1,358,628 (245)
Antibiotics, 2023 Helicobacter pylori (H. pylori) infection is ubiquitous worldwide, with prevalence rates of greater than 70% in Africa. Symptomatic patients present with foregut gastrointestinal symptoms which can be readily diagnosed with standardized non-invasive or ...
Mashiko Setshedi, Stella I. Smith
doaj +1 more source
Aging effect in nasal resistance.
Nippon Jibiinkoka Gakkai Kaiho, 1984 5歳から84歳までの鼻疾患,呼吸器疾患のない男女501例について,一方向流によるpassive anterior法にて鼻腔抵抗の測定を行い,5歳から16歳までの各年齢および15歳以上の6つの年齢群ごとの測定値を示し,年齢と鼻腔抵抗の変化につき検討を加え,次のような結果を得た.1) 5歳から16歳までの抵抗の変化は,a) 8歳までの抵抗の高い時期,b) それに続き11歳頃までの比較的急激に抵抗が低下する時期,およびc) それ以後の抵抗の変動が認められる時期の3つに分けられる.a)においてはアデノイドの存在が,b)においては鼻腔の大きさの増大とアデノイドの消退が,c)においては鼻腔や鼻甲介の発育の不均衡と自律神経系の影響が考えられた.2) 20歳以後の抵抗の変化には次の2つの特徴がみられた.a ...
openaire +3 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia
Emerging Infectious DiseasesBedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant tuberculosis. We report and discuss the unusual development of resistance to bedaquiline in a teenager in Namibia, despite an optimal background regimen and ...
Gunar Günther +9 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Frontiers in Oncology, 2022 Chemotherapy resistance represents a formidable obstacle in advanced or metastatic colorectal cancer (CRC) patients. It is reported that ATPase copper transporting alpha (ATP7A) plays an important role in chemotherapy resistance in CRC.
Yue Zhou +17 more
doaj +1 more source
Fully Dynamic Effective Resistances
, 2018 In this paper we consider the \emph{fully-dynamic} All-Pairs Effective Resistance problem, where the goal is to maintain effective resistances on a graph $G$ among any pair of query vertices under an intermixed sequence of edge insertions and deletions in $G$.
Durfee, David +3 more
openaire +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Effective Resistance Preserving Directed Graph Symmetrization [PDF]
SIAM Journal on Matrix Analysis and Applications, 2019 This work presents a new method for symmetrization of directed graphs that constructs an undirected graph with equivalent pairwise effective resistances as a given directed graph. Consequently a graph metric, square root of effective resistance, is preserved between the directed graph and its symmetrized version.
openaire +2 more sources