Results 101 to 110 of about 2,662,524 (294)

Efficient Immunization Strategies for Computer Networks and Populations

, 2003
We present an effective immunization strategy for computer networks and populations with broad and, in particular, scale-free degree distributions. The proposed strategy, acquaintance immunization, calls for the immunization of random acquaintances of ...
Daniel ben-Avraham, H. W. Hethcote, M. E. J. Newman, R. M. Anderson, Reuven Cohen, S. L. Feld, Shlomo Havlin   +6 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Correction to: The effective threshold dose of etanercept in patients with methotrexate-resistant rheumatoid arthritis. [PDF]

Clin Rheumatol, 2023
Chen F, Lang Y, Geng S, Wang X, Lu L, Ye S, Zhang L, Li T.   +7 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The effective threshold dose of etanercept in patients with methotrexate-resistant rheumatoid arthritis. [PDF]

Clin Rheumatol, 2023
Chen F, Lang Y, Geng S, Wang X, Lu L, Ye S, Zhang L, Li T.   +7 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Effect of pre-existing damage on delamination growth in repeatedly indented composites

Materials & Design
Improvements in current design approaches require further studies of the damage interaction effects of composite materials subjected to repeated out-of-plane concentrated loads.
L. Huo, C. Kassapoglou, R.C. Alderliesten   +2 more
doaj   +1 more source

Estimation of the cost-effective threshold of a quality-adjusted life year in China based on the value of statistical life. [PDF]

Eur J Health Econ, 2022
Cai D, Shi S, Jiang S, Si L, Wu J, Jiang Y.   +5 more
europepmc   +1 more source

RG-improvement of the effective action with multiple mass scales

, 2018
Improving the effective action by the renormalization group (RG) with several mass scales is an important problem in quantum field theories. A method based on the decoupling theorem was proposed in \cite{Bando:1992wy} and systematically improved \cite ...
Iso, Satoshi, Kawana, Kiyoharu
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source