UnZIPping Mechanisms of Effector-Triggered Immunity in Animals [PDF]
The mechanisms by which epithelial cells distinguish pathogens from commensal microbes have long puzzled us. Now, McEwan et al. (2012) and Dunbar et al. (2012), in this issue of Cell Host & Microbe, demonstrate that in C. elegans, microbial toxin-induced inhibition of host cellular functions, especially blockade of protein translation, activates the ...
Kleino, Anni, Silverman, Neal
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An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus [PDF]
The plant immune system is activated following the perception of exposed, essential and invariant microbial molecules that are recognised as non-self. A major component of plant immunity is the transcriptional induction of genes involved in a wide array ...
A Block +70 more
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The Immune Redoxome: Effector-Triggered Immunity Switches Cysteine Oxidation Profiles [PDF]
The changing climate impacts the interactions between plants and their surrounding environment, including pathogen invaders ([Mhamdi and Noctor, 2016][1]). Plant immune responses are often associated with increased production of reactive oxygen species (ROS), also known as the oxidative burst ...
Evan W. McConnell +6 more
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RhoGTPases--NODes for effector-triggered immunity in animals. [PDF]
A recent study published in Nature by Keestra and colleagues addresses how the immune system detects the pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which monitors the activation state of the RhoGTPases that are targeted by virulence effectors produced by pathogenic microbes.
Stuart LM, Boyer L.
europepmc +4 more sources
The soil-borne fungus Verticillium dahliae is causing a devastating vascular disease in more than 200 species of dicotyledonous plants. The pathogen attacks susceptible plants through the roots, colonizes the plant vascular system, and causes the death ...
Eirini G. Poulaki +3 more
doaj +1 more source
Proteomics of effector-triggered immunity (ETI) in plants. [PDF]
Effector-triggered immunity (ETI) was originally termed gene-for-gene resistance and dates back to fundamental observations of flax resistance to rust fungi by Harold Henry Flor in the 1940s. Since then, genetic and biochemical approaches have defined our current understanding of how plant "resistance" proteins recognize microbial effectors.
Hurley B +3 more
europepmc +4 more sources
xopAC-triggered immunity against Xanthomonas depends on Arabidopsis receptor-like cytoplasmic kinase genes PBL2 and RIPK. [PDF]
Xanthomonas campestris pv. campestris (Xcc) colonizes the vascular system of Brassicaceae and ultimately causes black rot. In susceptible Arabidopsis plants, XopAC type III effector inhibits by uridylylation positive regulators of the PAMP-triggered ...
Endrick Guy +6 more
doaj +1 more source
Engineering effector‐triggered immunity in rice: Obstacles and perspectives
AbstractImproving rice immunity is one of the most effective approaches to reduce yield loss by biotic factors, with the aim of increasing rice production by 2050 amidst limited natural resources. Triggering a fast and strong immune response to pathogens, effector‐triggered immunity (ETI) has intrigued scientists to intensively study and utilize the ...
Kieu Thi Xuan Vo +2 more
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Nuclear processes associated with plant immunity and pathogen susceptibility [PDF]
Plants are sessile organisms that have evolved exquisite and sophisticated mechanisms to adapt to their biotic and abiotic environment. Plants deploy receptors and vast signalling networks to detect, transmit and respond to a given biotic threat by ...
Huitema, Edgar +3 more
core +3 more sources
Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense [PDF]
The mammalian innate immune system deals with invading pathogens and stress by activating pattern-recognition receptors (PRRs) in the host. Initially proposed to be triggered by the discrimination of defined molecular signatures from pathogens rather than from self, it is now clear that PRRs can also be activated by endogenous ligands, bacterial ...
Thomas A, Kufer +2 more
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