The Effector Function of Allergens [PDF]
Allergens are antigens that generate an IgE response (sensitization) in susceptible individuals. The allergenicity of an allergen can be thought of in terms of its ability to sensitize as well as its ability to cross-link IgE/IgE receptor complexes on mast cells and basophils leading to release of preformed and newly formed mediators (effector activity)
Hazebrouck, Stéphane +2 more
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Insights into Phakopsora pachyrhizi Effector–Effector Interactions
The multifaceted role of pathogen-encoded effectors in plant–pathogen interactions is complex and not fully understood. Effectors operate within intricate host environments, interacting with host proteins and other effectors to modulate virulence.
Mingsheng Qi +5 more
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Effector Glycosyltransferases in Legionella [PDF]
Legionella causes severe pneumonia in humans. The pathogen produces an array of effectors, which interfere with host cell functions. Among them are the glucosyltransferases Lgt1, Lgt2 and Lgt3 from L. pneumophila. Lgt1 and Lgt2 are produced predominately in the post-exponential phase of bacterial growth, while synthesis of Lgt3 is induced mainly in the
Belyi, Yury +2 more
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Bioinformatic and functional characterisation of Globodera pallida effector genes [PDF]
Pathogens secrete molecules, termed effectors, to manipulate their host to the benefit of the pathogen. Effectors of plant parasitic nematodes are predicted to have a range of functions such as facilitating invasion, initiation and maintenance of the ...
Thorpe, Peter
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Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2 [PDF]
E. coli O157 carries two genes encoding the effector proteins NleH1 and NleH2 which are 87% identical. Despite the similarity between the proteins, the promoter regions upstream of the genes encoding the effectors are more divergent suggesting that the ...
Mitchell, T.J. +6 more
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The Complexity of Finding Effectors [PDF]
The NP-hard EFFECTORS problem on directed graphs is motivated by applications in network mining, particularly concerning the analysis of probabilistic information-propagation processes in social networks. In the corresponding model the arcs carry probabilities and there is a probabilistic diffusion process activating nodes by neighboring activated ...
Laurent Bulteau +4 more
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Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets [PDF]
Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naive central memory (T(CM)), effector memory (T(EM)), and effector memory RA (T(EMRA)) T cells using gene ...
Freeman, Tom +9 more
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Effectors and Effector Delivery in Magnaporthe oryzae
Rice blast caused by Magnaporthe oryzae is one of the most destructive fungal diseases of rice and a model for studying fungal-plant interactions. The fungus penetrates plant cells with appressoria and develops the narrow primary invasive hyphae (IH) and, subsequently, the bulbous secondary IH.
Zhang, Shijie, Xu, Jin-Rong
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Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1 [PDF]
Fungal and oomycete plant pathogens translocate effector proteins into host cells to establish infection. However, virulence targets and modes of action of their effectors are unknown.
Hein, I. +71 more
core +1 more source
Rapid turnover of effector-memory CD4(+) T cells in healthy humans [PDF]
Memory T cells can be divided into central-memory (T(CM)) and effector-memory (T(EM)) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar ...
Peter C.L. Beverley +26 more
core +1 more source

