Results 241 to 250 of about 5,384,327 (358)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Pathogenicity and virulence of <i>Phytophthora infestans</i>: The ever-evolving threat to food security and its sustainable management strategies. [PDF]

Virulence
Wang WJ, Li J, Zhao G, Wang YP, Fan S, Dong YQ, Yang LN, Zhan J.   +7 more
europepmc   +1 more source

Effect Estimates in Randomized Trials and Observational Studies: Comparing Apples With Apples [PDF]

, 2019
Sara Lodi, Andrew Phillips, Jens Lundgren, Roger Logan, Shweta Sharma, Stephen R. Cole, Abdel Babiker, Matthew Law, Haitao Chu, Dana Byrne, Andrzéj Horban, Jonathan A C Sterne, Kholoud Porter, Caroline Sabin, Dominique Costagliola, Sophie Abgrall, M. John Gill, Giota Touloumi, Antônio Guilherme Pacheco, Ard van Sighem, Peter Reiss, Heiner C. Bucher, Alexandra Montoliu Giménez, Inmaculada Jarrín, Linda Wittkop, Laurence Meyer, Santiago Pérez‐Hoyos, Amy C. Justice, James D. Neaton, Miguel A. Hernán   +29 more
openalex   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Functional and phenotypic analysis of CD4 T cell dynamics in peripheral blood of human visceral leishmaniasis patients confers increased frequencies of CD25 expressing regulatory T cells that contribute to disease pathogenesis. [PDF]

Front Immunol
Kamran M, Ghosh S, Bhattacharya P, Chaudhury SG, Bhattacharyya A, Banik G, Asad M, Ejazi SA, Madhukar M, Pandey K, Rahman M, Goswami RP, Ali N.   +12 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Metabolic hubs under attack: Effector-mediated manipulation of plant inositol phosphate signaling. [PDF]

PLoS Pathog
Roitsch E, Schaaf G, Lahaye T, Ried-Lasi MK.   +3 more
europepmc   +1 more source

Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies [PDF]

, 2018
Jessica Ruzzolini, Silvia Peppicelli, Elena Andreucci, Francesca Bianchini, Arianna Scardigli, Annalisa Romani, Giancarlo la Marca, Chiara Nediani, Lido Calorini   +8 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source