Results 111 to 120 of about 19,421,951 (301)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Location, location, location: the impact of migratory heterogeneity on T cell function
Frontiers in Immunology, 2013 T cell migration is crucial for an effective adaptive immune response to invading pathogens. Naive and memory T cells encounter pathogen antigens, become activated and differentiate into effector cells in secondary lymphoid tissues, and then migrate to ...
Bas J Baaten +3 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
The majority of CAR T cells are CD8+ effector or effector memory cells.
, 2016 Lineage (A; CD3+ CD8+), exhaustion phenotype (B; PD-1+ Tim-3+) and memory/effector status (C) were evaluated by flow cytometry at start and after co-culture with autologous B cells and IL-2 or IL-2 alone.
Camilla Gigg (839558) +7 more
core +1 more source
Frequencies and numbers of splenic central memory and effector memory T cells.
, 2022 (A) Representative flow cytometry gating strategy for identifying central memory, effector memory and naive T cells. (B) CD3+CD62L+CD44+CD4+ central memory T cells. (C). CD3+CD62L-CD44+CD4+ effector memory T cells.
Paballo Mosala (11822717) +7 more
core +1 more source
Iranian Journal of Allergy, Asthma and Immunology, 2018 Memory regulatory T cells (Tregs) has been demonstrated to produce IL-17 in Psoriasis. Forkhead box P3 (Foxp3) has been demonstrated not to be reliable marker to evaluate Treg cells. Effector CD4+T cells also express Foxp3 after activation.
Behnaz Esmaeili +3 more
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
The Journal of Clinical InvestigationVirus-induced memory T cells often express functional cross-reactivity, or heterologous immunity, to other viruses and to allogeneic MHC molecules that is an important component of pathogenic responses to allogeneic transplants.
Hidetoshi Tsuda +5 more
doaj +1 more source
Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs
eLife, 2020 The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4+ T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs).
Sofya A Kasatskaya +14 more
doaj +1 more source