Results 101 to 110 of about 19,421,951 (301)

Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells [PDF]

Cell Death & Disease, 2015
Abstract The transcriptional regulation underlying the differentiation of CD8 + effector and memory T cells remains elusive. Here, we show that 18-month-old mice lacking the transcription factor Smad4 (homolog 4 of mothers against decapentaplegic ...
Jingjing Cao, X Zhang, Q Wang, Guang Qiu, Chunmei Hou, J Wang, Qianqian Cheng, Yinghua Lan, Hua Han, Hao Shen, Y Zhang, Xiao Yang, Baihua Shen, J Zhang   +13 more
openaire   +2 more sources

Patients with B cell chronic lymphocytic leukaemia have an expanded population of CD4 perforin expressing T cells enriched for human cytomegalovirus specificity and an effector-memory phenotype

, 2009
We have previously shown an expansion of cytotoxic antigen-experienced CD4(+)T cells (CTLs) that express perforin (PF) in the peripheral blood of patients with B cell chronic lymphocytic leukaemia (B-CLL).
Akbar, Arne, Akbar, A., Lydyard, Peter M., Lydyard, P.M., Nathwani, Amit, Poraskishvili, Nino, Glennie, Martin J., Glennie, M.J., Emery, Vincent, Walton, James A., Walton, J.A., Nathwani, A., Emery, V., Porakishvili, N.   +13 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

miRNA Profiling of Naïve, Effector and Memory CD8 T Cells

PLoS ONE, 2007
microRNAs have recently emerged as master regulators of gene expression during development and cell differentiation. Although profound changes in gene expression also occur during antigen-induced T cell differentiation, the role of miRNAs in the process is not known. We compared the miRNA expression profiles between antigen-specific naïve, effector and
Wu, Haoquan, Neilson, Joel R., Kumar, Priti, Manocha, Monika, Shankar, Premlata, Sharp, Phillip A., Manjunath, N.   +6 more
openaire   +6 more sources

Modulation of CD8+ memory stem T cell activity and glycogen synthase kinase 3β inhibition enhances anti-tumoral immunity in gastric cancer

OncoImmunology, 2018
The potential contributions of CD8+ memory stem T cells to anti-tumor immunity and immunotherapy responses in gastric cancer has not been demonstrated.
Jin-yu Zhang, Yong-liang Zhao, Yi-pin Lv, Ping Cheng, Weisan Chen, Mubin Duan, Yong-sheng Teng, Ting-ting Wang, Liu-sheng Peng, Fang-yuan Mao, Yu-gang Liu, Xiao-long Fu, Pei-wu Yu, Ping Luo, Wei-jun Zhang, Quan-ming Zou, Yuan Zhuang   +16 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function

, 2010
Memory T cells develop early during the preclinical stages of autoimmune diseases and have traditionally been considered resistant to tolerance induction.
Steptoe, Raymond J., Waldie, Tanya, Thomas, Ranjeny, McNally, Alice, Thomson, Meagan, Yagita, Hideo, Kenna, Tony J.   +6 more
core   +1 more source

UMAP plot of 964 effector memory CD4⁺ T cells from peripheral blood of two healthy donors and four untreated celiac disease patients.

, 2021
HC: effector memory CD4+ T cells from healthy donors; Tet+T: sorted HLA-DQ2:gluten-tetramer-positive effector memory CD4+ T cells from CD patients; Tet-T: tetramer-negative effector memory CD4+ T cells from CD patients. (PDF)
Ying Yao (241857), Shuo-Wang Qiao (359549), Łukasz Wyrozżemski (11534911), Knut E. A. Lundin (8878640), Geir Kjetil Sandve (10291229)   +4 more
core   +1 more source

CD8 T Cells and Toxoplasma gondii: A New Paradigm

Journal of Parasitology Research, 2011
CD8 T cells are essential for control of Toxoplasma gondii infection. Once activated they undergo differentiation into short-lived effector and memory precursor effector cells.
Jason P. Gigley, Rajarshi Bhadra, Imtiaz A. Khan   +2 more
doaj   +1 more source

G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment

Frontiers in Immunology, 2018
The requirements for effector and memory CD8 T cell development are incompletely understood. Recent work has revealed a role for G-protein coupled receptor 18 (GPR18) in establishment of the intestinal CD8αα intraepithelial lymphocyte compartment.
Hayakazu Sumida, Jason G. Cyster
doaj   +1 more source