Results 81 to 90 of about 19,421,951 (301)

T cells in vascular inflammatory diseases

Frontiers in Immunology, 2014
Inflammation of the human vasculature is a manifestation of many different diseases ranging from systemic autoimmune diseases to chronic inflammatory diseases, in which multiple types of immune cells are involved. For both autoimmune diseases and chronic
Lucas L Lintermans, Coen A Stegeman, Peter eHeeringa, Wayel H Abdulahad   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

E4BP4 restrains effector-memory CD8+ T cell responses in systemic lupus erythematosus

Autoimmunity
Increasing evidence shows that CD8+ T cells are the pathogenic mediators of tissue injury in systemic lupus erythematosus (SLE), sustaining the chronic inflammation through the accumulation of long-lived cytotoxic memory populations.
Ming Zhu, Suqing Zhou, Changxing Gao, Yanshan Zhu, Xieling He, Qianjin Lu, Ming Zhao, Zijun Wang   +7 more
doaj   +1 more source

Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure

Frontiers in Immunology, 2019
Recent studies demonstrate that the stable HIV-1 reservoir in resting CD4+ T cells is mostly formed from viruses circulating when combination antiretroviral therapy (ART) is initiated.
Nilu Goonetilleke, Nilu Goonetilleke, Genevieve Clutton, Genevieve Clutton, Ron Swanstrom, Ron Swanstrom, Sarah B. Joseph, Sarah B. Joseph, Sarah B. Joseph   +8 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Differentiation of Human CD8+ T Cells from a Memory to Memory/Effector Phenotype [PDF]

The Journal of Immunology, 2002
Abstract Previous studies of perforin expression and cytokine production in subsets of peripheral human CD45RA−CD8+ T cells with different CD28/CD27 phenotypes showed that CD28+CD45RA−CD8+ and CD27+CD45RA−CD8+ T cells have characteristics of memory T cells, whereas CD28−CD45RA−CD8+ and CD27−CD45RA−CD8+ T cells have characteristics of ...
Hiroko, Tomiyama, Tomoko, Matsuda, Masafumi, Takiguchi   +2 more
openaire   +2 more sources

Effector-memory Maxi CD8 T cells are maintained in lungs independently of antigen and have longer half-lives than effector Maxi CD8 T cells.

, 2018
(A) Naïve Maxi CD8 T cells were adoptively transferred into naïve C57BL/6 mice followed by i. v. MCMVΔm157 infection. Effector-memory Maxi CD8 T cells were sorted from the lungs and transferred into infection-matched or naïve recipients. Total numbers of
Koichi Ikuta (5100953), Mariana Borsa (5100956), Nicole Torti (199024), Nicolas S. Baumann (5100950), Katharina Pallmer (5100959), Jennifer D. Oduro (3385988), Luka Cicin-Sain (3385982), Isabel Barnstorf (5100962), Suzanne P. M. Welten (142809), Annette Oxenius (141998), Burkhard Ludewig (78075)   +10 more
core   +1 more source

Persistence of an intact HIV reservoir in phenotypically naive T cells

JCI Insight, 2020
Despite the efficacy of antiretroviral therapy (ART), HIV persists in a latent form and remains a hurdle to eradication. CD4+ T lymphocytes harbor the majority of the HIV reservoir, but the role of individual subsets remains unclear.
Emmanuele Venanzi Rullo, Marilia Rita Pinzone, LaMont Cannon, Sam Weissman, Manuela Ceccarelli, Ryan Zurakowski, Giuseppe Nunnari, Una O’Doherty   +7 more
doaj   +1 more source

TSC2 S1365A mutation potently regulates CD8+ T cell function and differentiation and improves adoptive cellular cancer therapy

JCI Insight, 2023
MTORC1 integrates signaling from the immune microenvironment to regulate T cell activation, differentiation, and function. TSC2 in the tuberous sclerosis complex tightly regulates mTORC1 activation.
Chirag H. Patel, Yi Dong, Navid Koleini, Xiaoxu Wang, Brittany L. Dunkerly-Eyring, Jiayu Wen, Mark J. Ranek, Laura M. Bartle, Daniel B. Henderson, Jason Sagert, David A. Kass, Jonathan D. Powell   +11 more
doaj   +1 more source