Results 71 to 80 of about 19,421,951 (301)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Understanding the slow depletion of memory CD4(+) T cells in HIV infection [PDF]

, 2007
Background The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood.
Nigel Klein, Klein Nigel, Antia, Rustom, Yates, Andrew, Callard, Robin, Antia Rustom, Yates, A, Callard, R, Klein, Nigel, Jaroslav Stark, Stark, J, Andrew Yates, Stark Jaroslav, Rustom Antia, Callard Robin, Stark, Jaroslav, Yates Andrew, Robin Callard, Klein, N, Antia, R   +19 more
core   +2 more sources

Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis.

PLoS Pathogens, 2022
Initial TCR engagement (priming) of naive CD8+ T cells results in T cell expansion, and these early events influence the generation of diverse effector and memory populations.
Lindsey A Shallberg, Anthony T Phan, David A Christian, Joseph A Perry, Breanne E Haskins, Daniel P Beiting, Tajie H Harris, Anita A Koshy, Christopher A Hunter   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Differential Microenvironment Localization of Effector and Memory CD8 T Cells [PDF]

The Journal of Immunology, 2008
Abstract CD8 T cells are critical for the clearance of intracellular pathogens. Upon infection, naive CD8 T cells differentiate into effector cells that target and eliminate infected cells. Following clearance of the pathogen, most effector cells die, although a small fraction survives to establish a memory population.
Joseph G, Dauner, Ifor R, Williams, Joshy, Jacob   +2 more
openaire   +2 more sources

Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

, 2020
The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its cessation and associates with effects on CD4+ T cells.
Moreira, Marcela L, Laohamonthonkul, Pawat, Lansink, Lianne IM, Engel, Jessica A, Clarke, Lachlan S, Soon, Megan SF, Haldar, Rohit N, Straube, Jasmin, Bramhall, Michael, Thomas, Bryce S, Lee, Hyun Jae, Pernold, Clara PS, Engwerda, Christian R, Williams, Cameron G, et al.   +14 more
core   +2 more sources

Distinct epitope-specific memory kinetics within influenza B nucleoprotein shape long-term CD8+ T cell differentiation in the lung

Frontiers in Immunology
CD8+ T cell memory inflation, originally described during murine cytomegalovirus infection, is characterized by the progressive accumulation of antigen-specific memory T cells that retain effector-like features rather than undergoing gradual contraction.
Serin Lee, Eun-Ah Kim, Sun Shim Choi, Jun Chang   +3 more
doaj   +1 more source

Naïve, Effector, and Memory T cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting [PDF]

International Journal of Nutrition Sciences
Background: Intermittent fasting (IF) is a 16/8 fasting model, which is supposed to recruit immune cells to the bone marrow, thus prevents immune exhaustion.
Sara Assadiasl, Narjes Soleimanifar, Mohammad Hassan Alamolhoda, Hanieh Mojtahedi, Maryam Sadr, Sepehr Safdel, Zahra Mozooni, Mohammad Hossein Nicknam   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Developmental epigenetic programming by Tet1/3 determines peripheral CD8 T cell fate

EMBO Reports
In response to infections, naive CD8 T cells give rise to effector and memory T cells. However, eliciting long-lived memory CD8 T cells remains a challenge for many infections.
Kara M Misel-Wuchter, Andrew L Thurman, Jordan T Johnson, Athmane Teghanemt, Neelam Gautam, Alejandro A Pezzulo, Jennifer R Bermick, Noah S Butler, Priya D Issuree   +8 more
doaj   +1 more source