Results 141 to 150 of about 19,421,951 (301)

L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells

, 2007
T lymphocytes lacking the lymph node-homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin ...
Lanzavecchia, Antonio, Guarda, G, Hons, M, Polley, Rosalind, Stein, J V, Antonio Lanzavecchia, Sallusto, F, Miroslav Hons, Guarda, Greta, Alfonso Martín-Fontecha, Martin-Fontecha, A, Lanzavecchia, A, Sallusto, Federica, Polley, R, Hons, Miroslav, Jens V Stein, Federica Sallusto, Germain, Ronald N, Martín-Fontecha, Alfonso, Rosalind Polley, Huang, Alex Y, Greta Guarda, Stein, Jens V, Ronald N Germain, Huang, A Y, Germain, R N, Silvia F Soriano, Alex Y Huang, Soriano, Silvia F, Soriano, S F, Stein, Jens Volker   +30 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4(+) T cells

, 2003
Memory T lymphocytes divide in vivo in the absence of antigen maintaining a pool of central memory (T-CM) and effector memory cells (T-EM) with distinct effector function and homing capacity.
Sallusto F, Geginat J, Lanzavecchia A
core   +1 more source

IFNγ Transcribed by IRF1 in CD4+ Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis. [PDF]

Aging Dis, 2023
Chen H, Wang Q, Li J, Li Y, Chen A, Zhou J, Zhao J, Mao Z, Zhou Z, Zhang J, Wang Y, Wang R, Li Q, Zhang Y, Jiang R, Miao D, Jin J.   +16 more
europepmc   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Mean percentage +/- SEM naïve, effector, central memory, and effector memory CD4+ cells gated off CD4+ T cells in PB and at the UPI of healthy and preeclamptic (PE) patients, see also Fig 1A+1C.

, 2018
Mean percentage +/- SEM naïve, effector, central memory, and effector memory CD4+ cells gated off CD4+ T cells in PB and at the UPI of healthy and preeclamptic (PE) patients, see also Fig 1A+1C.
Andrea I. Loewendorf (566385), Daniel A. Kahn (566388), Tina A. Nguyen (566386)   +2 more
core   +1 more source

Vaccination and immunological memory

, 2008
Human subjects maintain long-term immunological memory against infective organisms but the mechanism is unclear. CD4+ T helper memory cells (Thmem) are pivotal in controlling humoral and cellular responses, therefore their longevity and response to ...
Di Genova, Gianfranco
core   +1 more source

Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells. [PDF]

Cell Rep, 2023
Meibers HE, Warrick KA, VonHandorf A, Vallez CN, Kawarizadeh K, Saha I, Donmez O, Jain VG, Kottyan LC, Weirauch MT, Pasare C.   +10 more
europepmc   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source