Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source
Predominance of effector-memory T-cells after allogeneic stimulation was enhanced by belatacept.
, 2016 A representative sample of 33 measurements is depicted for the gating strategy of the memory subsets within the proliferated, alloreactive CD8POS T-cells after 7 days of allo-antigen stimulation, in the presence and abcense of belatacept, as well as the ...
Marjolein Dieterich (2502907) +5 more
core +1 more source
Inflammatory and immune markers in HIV-infected older adults on long-term antiretroviral therapy: Persistent elevation of sCD14 and of proinflammatory effector memory T cells. [PDF]
Aging Cell, 2022 Watanabe M +9 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto +12 more
wiley +1 more source
Effector Memory T Cells and CD45RO+ Regulatory T Cells in Metastatic vs. Non-Metastatic Lymph Nodes in Lung Cancer Patients. [PDF]
Front Immunol, 2022 Kwiecień I +7 more
europepmc +1 more source
Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong +10 more
wiley +1 more source
A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma. [PDF]
Sci Transl Med, 2021 Konduri V +19 more
europepmc +1 more source
Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali +4 more
wiley +1 more source
Effector memory T-cell responses.
, 2012 Percentages of effector memory T-cells (CD45RA-,CCR7-) in children of 4 years (red filled circles) and 9 years of age (blue filled circles) found in CD3+CD4+ T-cells (A) and proliferated (CFSE-) CD3+CD4+ T-cells (B) upon stimulation with the pertussis ...
Kemal Öztürk (146182) +6 more
core +1 more source
The function and origin of the CD4+ T cell in the classical Hodgkin lymphoma microenvironment [PDF]
, 2012 PhDClassical Hodgkin lymphoma (CHL) is a germinal centre B cell malignancy where the bulk of the tumour comprises a non-clonal immune infiltrate enriched for CD4+ T cells.
Greaves, Paul
core +1 more source