Results 41 to 50 of about 19,421,951 (301)

Altered circulating CCR6+and CXCR3+ T cell subsets are associated with poor renal prognosis in MPO-ANCA-associated vasculitis

Arthritis Research & Therapy, 2021
Background Effector memory T cells are pivotal effectors of adaptive immunity with enhanced migration characteristics and are involved in the pathogenesis of ANCA-associated vasculitis (AAV). The diversity of effector memory T cells in chemokine receptor
Zhonghua Liao, Jiale Tang, Liying Luo, Shuanglinzi Deng, Lisa Luo, Fangyuan Wang, Xiangning Yuan, Xinyue Hu, Juntao Feng, Xiaozhao Li   +9 more
doaj   +1 more source

Altered T cell memory and effector cell development in chronic lymphatic filarial infection that is independent of persistent parasite antigen. [PDF]

PLoS ONE, 2011
Chronic lymphatic filarial (LF) infection is associated with suppression of parasite-specific T cell responses that persist even following elimination of infection.
Cathy Steel, Thomas B Nutman
doaj   +1 more source

Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells [PDF]

Frontiers in Immunology, 2014
Inflammatory cytokines have long been recognized to produce potent APCs to elicit robust T cell responses for protective immunity. The impact of inflammatory cytokine signaling directly on T cells, however, has only recently been appreciated. Although much remains to be learned, the CD8 T cell field has made considerable strides in understanding the ...
Kim, Marie T., Harty, John T.
openaire   +3 more sources

Down-Regulation of Surface CD28 under Belatacept Treatment: An Escape Mechanism for Antigen-Reactive T-Cells. [PDF]

PLoS ONE, 2016
BACKGROUND:The co-stimulatory inhibitor of the CD28-CD80/86-pathway, belatacept, allows calcineurin-inhibitor-free immunosuppression in kidney transplantation.
Gretchen N de Graav, Dennis A Hesselink, Marjolein Dieterich, Rens Kraaijeveld, Willem Weimar, Carla C Baan   +5 more
doaj   +1 more source

Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection [PDF]

Current Immunology Reviews, 2014
As effector memory T cells (Tem) are the predominant population elicited by chronic parasitic infections, increasing our knowledge of their function, survival and derivation, as phenotypically and functionally distinct from central memory and effector T cells will be critical to vaccine development for these diseases. In some infections, memory T cells
Opata, Michael M., Stephens, Robin
openaire   +2 more sources

Freeze-thaw lysates of Plasmodium falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells. [PDF]

, 2012
In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to TCR stimulation with cytokine costimulation.
Finney, Olivia C, Riley, Eleanor M, Finney, OC, Lawrence, Emma, Gray, Alice P, Njie, Madi, Walther, M, Walther, Michael, Riley, EM, Gray, AP, Lawrence, E, Njie, M   +11 more
core   +1 more source

Death of effector memory T cells characterizes AIDS

Frontiers in Bioscience, 2009
The adaptive effector CD4+ T helper-mediated immune response is highly heterogeneous, based on the development of distinct subsets that are characterized by the expression of different profiles of cell surface markers. Functional impairment of T cells is characteristic of many chronic mouse and human viral infections.
Laforge, Mireille, Senik, Anna, Cumont, Marie-Christine, Monceaux, Valerie, Hurtrel, Bruno, Estaquier, Jerome   +5 more
openaire   +2 more sources

WASp Is Essential for Effector-to-Memory conversion and for Maintenance of CD8+T Cell Memory [PDF]

Frontiers in Immunology, 2019
Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency characterized by recurrent infections, micro thrombocytopenia, eczema, and a high incidence of autoimmunity and malignancy. A defect in the T cell compartment is thought to be a major cause of immunodeficiency in patients with WAS; However, whether the antigen specific T memory ...
Qiao Liu, Liang Zhang, Zhou Shu, Tingting Yu, Lina Zhou, Lina Zhou, Wenxia Song, Xiaodong Zhao, Xiaodong Zhao, Xiaodong Zhao   +9 more
openaire   +3 more sources

The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells [PDF]

, 2007
We have addressed the role of the inducible costimulator (ICOS) in the development of T cell help for B cells and in the generation, survival and reactivation of memory CD4 T cells and B cells.
MacDonald, Andrew, Mahajan, Simmi, Fillatreau, Simon, Cervera, Ana, MacDonald, Andrew; id_orcid, Smith, Andrew, Gray, David, Ana Cervera, Perona-Wright, Georgia, Macleod, Megan, Andrew Smith, Stephen Meek, Megan MacLeod, Andrew MacDonald, Meek, Stephen, Simmi Mahajan, David Gray, Georgia Perona‐Wright, Simon Fillatreau   +18 more
core   +1 more source

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4+ CD25high T cells with susceptibility in Kenyans [PDF]

, 2008
Background - Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection ...
Magdalena Plebanski, Stephen M. Todryk, Plebanski Magdalena, Hill, Adrian, Tabitha Mwangi, Kevin Marsh, Urban Britta, Flanagan Katie L., Mwangi Tabitha, Plebanski, Magdalena, Britta Urban, Todryk, Stephen, Hill Adrian V. S., Urban, Britta, Katie L Flanagan, Philip Bejon, Bejon, Philip, Marsh Kevin, Mwangi, Tabitha, Flanagan, Katie, Bejon Philip, Katie L. Flanagan, Adrian V S Hill, Todryk Stephen M., Adrian V. S. Hill, Stephen M Todryk, Marsh, Kevin   +26 more
core   +1 more source