Results 21 to 30 of about 19,421,951 (301)

Autoimmune effector memory T cells: the bad and the good [PDF]

Immunologic Research, 2013
Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed to vertebrates during evolution. However, an autoimmune pathogenic role of memory lymphocytes is also emerging with accumulating evidence, despite reasonable skepticism on their existence in a chronic setting of autoimmune damage.
Priyadharshini, Devarajan, Zhibin, Chen
openaire   +2 more sources

Active maintenance of CD8+ T cell naivety through regulation of global genome architecture

Cell Reports, 2023
Summary: The differentiation of naive CD8+ T lymphocytes into cytotoxic effector and memory CTL results in large-scale changes in transcriptional and phenotypic profiles. Little is known about how large-scale changes in genome organization underpin these
Brendan E. Russ, Adele Barugahare, Pushkar Dakle, Kirril Tsyganov, Sara Quon, Bingfei Yu, Jasmine Li, Jason K.C. Lee, Moshe Olshansky, Zhaohren He, Paul F. Harrison, Michael See, Simone Nussing, Alison E. Morey, Vibha A. Udupa, Taylah J. Bennett, Axel Kallies, Cornelis Murre, Phillipe Collas, David Powell, Ananda W. Goldrath, Stephen J. Turner   +21 more
doaj   +1 more source

Rapid Effector Function in CD8+ Memory T Cells [PDF]

The Journal of Experimental Medicine, 1997
The nature of the CD8+ T cells that underlie antiviral protective immunological memory in vivo is unclear. We have characterized peptide-specific CD8+ T lymphocytes directly ex vivo from peripheral blood in humans with past exposure to influenza virus, using single cell interferon γ (IFN-γ) release as a measure of effector function.
Lalvani, A, Brookes, R, Hambleton, S, Britton, W, Hill, A, McMichael, A   +5 more
openaire   +3 more sources

Effector and memory T cell responses to commensal bacteria [PDF]

Trends in Immunology, 2013
Barrier surfaces are home to a vast population of commensal organisms that together encode millions of proteins; each of them possessing several potential foreign antigens. Regulation of immune responses to this enormous antigenic load represents a tremendous challenge for the immune system.
Yasmine, Belkaid, Nicolas, Bouladoux, Timothy W, Hand   +2 more
openaire   +2 more sources

Memory T Cells Discrepancies in COVID-19 Patients

Microorganisms, 2023
The immune response implicated in Coronavirus disease 2019 (COVID-19) pathogenesis remains to be fully understood. The present study aimed to clarify the alterations in CD4+ and CD8+ memory T cells’ compartments in SARS-CoV-2-infected patients, with an ...
Hajir A. Al Saihati, Hosni A. M. Hussein, Ali A. Thabet, Ahmed A. Wardany, Sabry Y. Mahmoud, Eman S. Farrag, Taha I. A. Mohamed, Samah M. Fathy, Mohamed E. Elnosary, Ali Sobhy, Abdelazeem E. Ahmed, Ahmed M. El-Adly, Fareed S. El-Shenawy, Asmaa A. Elsadek, Amal Rayan, Zeinab Albadry M. Zahran, Omnia El-Badawy, Mohamed G. M. El-Naggar, Magdy M. Afifi, Asmaa M. Zahran   +19 more
doaj   +1 more source

Heterogeneity of the Memory CD4 T Cell Response: Persisting Effectors and Resting Memory T Cells [PDF]

The Journal of Immunology, 2001
Abstract Defining the cellular composition of the memory T cell pool has been complicated by an inability to distinguish effector and memory T cells. We present here an activation profile assay, using anti-CD3 and antigenic stimuli, that clearly distinguishes effector and memory CD4 T cells and defines subsets of long-lived memory CD4
M, Ahmadzadeh, S F, Hussain, D L, Farber
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Mitochondrial Dysfunction in CD4+ T Effector Memory RA+ Cells

Biology, 2023
Human ageing is accompanied by poor responses to infection and decreased vaccine efficacy. While the causes of this can be attributed to defects in the immune system that increase with age, it is unknown whether mitochondrial dysfunction may also contribute to these phenomena.
Marie Strickland, Salanne Lee, Shi Yong Neo, Akhila Balachander, Ivy Low, Seri Mustafah, Wah Ing Goh, Graham D. Wright, Anis Larbi, Sylvia L. F. Pender   +9 more
openaire   +5 more sources

Dicer Regulates the Balance of Short-Lived Effector and Long-Lived Memory CD8 T Cell Lineages. [PDF]

PLoS ONE, 2016
MicroRNAs constitute a major post-transcriptional mechanism for controlling protein expression, and are emerging as key regulators during T cell development and function. Recent reports of augmented CD8 T cell activation and effector differentiation, and
Florian M Baumann, Yevgeniy Yuzefpolskiy, Surojit Sarkar, Vandana Kalia   +3 more
doaj   +1 more source

GOT1 regulates CD8+ effector and memory T cell generation

Cell Reports, 2023
T cell activation, proliferation, function, and differentiation are tightly linked to proper metabolic reprogramming and regulation. By using [U-13C]glucose tracing, we reveal a critical role for GOT1 in promoting CD8+ T cell effector differentiation and function.
Wei Xu, Chirag H. Patel, Liang Zhao, Im-Hong Sun, Min-Hee Oh, Im-Meng Sun, Rachel S. Helms, Jiayu Wen, Jonathan D. Powell   +8 more
openaire   +3 more sources

NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells

Cell Reports, 2019
Summary: Autophagy plays a critical role in the maintenance of immunological memory. However, the molecular mechanisms involved in autophagy-regulated effector memory formation in CD8+ T cells remain unclear. Here we show that deficiency in NIX-dependent
Shubhranshu S. Gupta, Robert Sharp, Colby Hofferek, Le Kuai, Gerald W. Dorn, II, Jin Wang, Min Chen   +6 more
doaj   +1 more source