Results 11 to 20 of about 19,421,951 (301)

T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells. [PDF]

PLoS ONE, 2013
Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
Gang Li, Qianting Yang, Yibei Zhu, Hong-Rui Wang, Xinchun Chen, Xueguang Zhang, Binfeng Lu   +6 more
doaj   +3 more sources

Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans [PDF]

The Journal of Experimental Medicine, 2004
Memory T cells can be divided into central–memory (TCM) and effector–memory (TEM) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar mechanisms.
Macallan, D, Wallace, D, Zhang, Y, De Lara, C, Worth, A, Ghattas, H, Griffin, G, Beverley, P, Tough, D   +8 more
openaire   +6 more sources

PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection

Frontiers in Immunology, 2021
Effective T cell differentiation during acute virus infections leads to the generation of effector T cells that mediate viral clearance, as well as memory T cells that confer protection against subsequent reinfection.
Roberto Tinoco, Emily N. Neubert, Christopher J. Stairiker, Monique L. Henriquez, Linda M. Bradley   +4 more
doaj   +1 more source

Lineage relationship of effector and memory T cells [PDF]

Current Opinion in Immunology, 2013
Adaptive immunity is characterized by the ability to form long-lived immunological memory. Upon re-exposure to antigen, memory T cells respond more rapidly and robustly than naïve T cells, providing better clearance of pathogens. Recent reviews have reinforced the text-book view that memory T cells arise from effector cells.
Nicholas P, Restifo, Luca, Gattinoni
openaire   +2 more sources

Distinct CD4−CD8− (Double-Negative) Memory T-Cell Subpopulations Are Associated With Indeterminate and Cardiac Clinical Forms of Chagas Disease

Frontiers in Immunology, 2021
CD4−CD8− (double-negative, DN) T cells are critical orchestrators of the cytokine network associated with the pathogenic inflammatory response in one of the deadliest cardiomyopathies known, Chagas heart disease, which is caused by Trypanosoma cruzi ...
Livia Silva Araújo Passos, Livia Silva Araújo Passos, Carolina Cattoni Koh, Luísa Mourão Dias Magalhães, Luísa Mourão Dias Magalhães, Maria do Carmo Pereira Nunes, Kenneth John Gollob, Kenneth John Gollob, Walderez Ornelas Dutra, Walderez Ornelas Dutra, Walderez Ornelas Dutra   +10 more
doaj   +1 more source

SnapShot: Effector and Memory T Cell Differentiation [PDF]

Journal of End-to-End-testing, 2009
The differentiation of T cells is an ideal system to study the molecular basis of lineage specification in mammalian cells. Upon stimulation with antigen during infection or inflammation, naive peripheral T cells differentiate into various types of effector T cells with specific immune functions.
Pipkin, Matthew E., Rao, Anjana
openaire   +2 more sources

Sirtuin 5 is Dispensable for CD8+ T Cell Effector and Memory Differentiation

Frontiers in Cell and Developmental Biology, 2021
CD8+ T cell effector and memory differentiation is tightly controlled at multiple levels including transcriptional, metabolic, and epigenetic regulation.
Qianqian Duan, Qianqian Duan, Jiying Ding, Jiying Ding, Jiying Ding, Fangfang Li, Fangfang Li, Fangfang Li, Xiaowei Liu, Xiaowei Liu, Yunan Zhao, Hongxiu Yu, Yong Liu, Yong Liu, Yong Liu, Lianjun Zhang, Lianjun Zhang, Lianjun Zhang   +17 more
doaj   +1 more source

Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets [PDF]

, 2005
Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naive central memory (T(CM)), effector memory (T(EM)), and effector memory RA (T(EMRA)) T cells using gene ...
Freeman, Tom, Hasegawa, Hitoshi, Willinger, Tim, Callan, Margaret F C, McMichael, Andrew J, Willinger, T, Freeman, T, Callan, MF, Hasegawa, H, Mcmichael, Andrew   +9 more
core   +2 more sources

Molecular regulation of effector and memory T cell differentiation [PDF]

Nature Immunology, 2014
Immunological memory is a cardinal feature of adaptive immunity and an important goal of vaccination strategies. Here we highlight advances in the understanding of the diverse T lymphocyte subsets that provide acute and long-term protection from infection.
John T, Chang, E John, Wherry, Ananda W, Goldrath   +2 more
openaire   +2 more sources

Cytomegalovirus infection and progressive differentiation of effector-memory T cells. [PDF]

F1000Res, 2018
Primary cytomegalovirus (CMV) infection leads to strong innate and adaptive immune responses against the virus, which prevents serious disease. However, CMV infection can cause serious morbidity and mortality in individuals who are immunocompromised.
Pardieck IN, Beyrend G, Redeker A, Arens R.   +3 more
europepmc   +4 more sources