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How ras-related proteins talk to their effectors
Trends in Biochemical Sciences, 1996More and more effectors for the Ras-related protein superfamily are being discovered and it is emerging that these GTP-binding proteins interact with more than one effector to generate more than one cellular signal. Atomic details for the interaction of Rap/Ras with one of the effectors, the protein kinase c-Raf-1, have recently become available by X ...
Wittinghofer, A., Nassar, N.
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[Effector proteins of Clamidia].
Molekuliarnaia biologiia, 2010The review summarizes the recent published data on molecular mechanisms of Chlamidiae - host cell interaction, first of all on chlamydial effector proteins. Such proteins as well as III transport system proteins that transfer many effector proteins into host cytoplasm are attractive targets for drug therapy of chlamydial infections. The majority of the
A S, Kariagina +4 more
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Activators and effectors of ras p21 proteins
Current Opinion in Genetics & Development, 1994Over the past year, major advances have been made in understanding the key steps involved in signaling pathways--from receptor tyrosine kinases to ras p21, and on to a cascade of serine/threonine kinases. A chain of specific protein-protein interactions is responsible for signal transduction. Components of the pathway are highly conserved between flies,
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Molecular Mimicry by Bacterial Effector Proteins
Journal of Basic MicrobiologyABSTRACTMicroorganisms have developed sophisticated mechanisms to invade the host and evade the host's immune surveillance while exploiting the host's resources for their establishment through co‐evolution. Many pathogens employ specialized protein secretion systems to transport virulence factors from the bacterial cytosol into host cells.
Aakar Anshul, Pooja Kumari
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Phosphorylated Proteins as Physiological Effectors
Science, 1978A variety of neurotransmitters, hormones, and other regulatory agents affect the phosphorylation of specific proteins in their target tissues. The types of stimuli that share this common effect on protein phosphorylation include numerous substances that do not act through cyclic AMP.
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Bacterial Protein Toxins and Effectors
2019In this chapter, we discuss the function and mechanism of action of secreted or delivered bacterial protein toxins and effectors. The multitude of their effects on host cell physiology, architecture, signaling, and survival is framed in the context of the advantage their activity has on the success of the bacterium during infection.
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G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)
Pharmacology & Therapeutics, 2022Javier González-Maeso +2 more
exaly