Results 141 to 150 of about 17,233,771 (291)

Division of Environmental Hazards & Health Effects [PDF]

open access: yes
CDC\u2019s Division of Environmental Hazards & Health Effects (EHHE) focuses primarily on the following:\u2022 Air Pollution and Respiratory Health\u2022 Chemical and Radiologic Terrorism\u2022 Environmental Public Health Tracking\u2022 Health Studies ...

core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Workshop on effects-based approaches for heavy metals Proceedings

open access: yes, 1999
The workshop of 'Effects-Based Approaches for Heavy Metals', held in October 1999 in Schwerin, Germany, marked a further milestone in the development of calculation methods to derive effects-based critical limits and critical loads for these air ...
Gregor, H.D.   +3 more
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Civil Effects Test Operations Report CEX-59.1

open access: yes, 1959
: "An experimental study was made to determine the effective shielding provided by a modern reinforced-concrete office building (AEC Headquarters building) from nuclear fallout.
Kaplan, A. L.   +2 more
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Effects

open access: yes, 2008
This thesis extends and updates the N__qodal Design of Actuators and Sensors (NODAS) library previously developed at Carnegie Mellon University. NODAS is a library of atomic element lumped parameter behavioral models written in Verilog-A, an analog ...
Mems Electrostatic   +4 more
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

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