Results 151 to 160 of about 17,233,771 (291)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Side effects of Methylphenidate

, 2018
The thesis describes the variable Side effects of Methylphenidate, its mechanism of action, indications, contraindications and the possible positive and negative effects methylphenidate can induce in the human body, based on a wide review of 63 different
Mazor, Shabi
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Individual Differences in Sleep Quality: Exploring the Impact of Temperament on Sleep Through Anxiety and Depression. [PDF]

Personal Ment Health
Lasaponara S, Scuderi A, Pellegrini E, Annarumma L, Piga V, Lo Presti S, Gorgoni M.   +6 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Effects from gender mainstreaming

, 2013
An important issue in recent years in the gender equality field deals with effects produced by gender equality initiatives. Reports of difficulties such as resistance, obstacles and a lack of resources are common and have occurred for as long as gender ...
Callerstig, Anne-Charlott,, Lindholm, Kristina,   +1 more
core  

Extended Long-Term Effects of Cognitive and Aerobic Training on Cognitive Function in Patients With Stress-Related Exhaustion Disorder: A 4.5-Year Follow-Up of a Randomized Controlled Trial. [PDF]

Stress Health
Aronsson I, Neely AS, Boraxbekk CJ, Eskilsson T, Gavelin HM.   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Association Between Danish Guideline Treatments for Breast Cancer and Physiotherapy-Relevant Late Effects: A Nationwide Cohort Study. [PDF]

Physiother Res Int
Feder KM, Stokholm L, Rahr HB, Ingwersen KG, Lautrup MD.   +4 more
europepmc   +1 more source