Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Non-Biologic Injections in Sports Medicine. [PDF]
Curr Rev Musculoskelet MedGrusky AZ +3 more
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Side effects, perverse effects an other strange effects of public interventions
, 2013 Large projects financed by the EU are always evaluated. But are these evaluations looking for long-term effects? It is no simple task to capture effects of programmes and projects.
Vedung, Evert,
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Nature-based meaning-focused photography intervention enhances subjective well-being: A three-arm randomized controlled study. [PDF]
Appl Psychol Health Well BeingChen Y, Zhang Y, Liu J, Gan Y.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Mixed Models and Longitudinal Data
, 2007 did in the case of the fixed effects model. It follows that the computational procedure and the analysis of variance table are the same as in the fixed effects case, although the conclusions are different since in the random effects case they apply to ...
Random Effects Consider
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Understanding Auditory Temporal Processing in Chinese Children With Dyslexia: The Mediating Effect of Phonological Awareness and Rapid Automatised Naming. [PDF]
DyslexiaWang J, Long J, Li J, Wang P.
europepmc +1 more source