Results 111 to 120 of about 6,699,838 (364)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Perceived efficacy and attitudes towards genetic science and science governance
, 2010 This is the postprint version of the Article. The official published version can be obtained from the link below - © 2010 SAGE Publications.Arguments for public involvement in science and technology are often based on ideas of developing a more capable ...
Barnett, Julie +4 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis.
, 2006 BACKGROUND: Aminosalicylates are the mainstay of therapy to prevent relapse of quiescent ulcerative colitis. The rationale for using probiotics is based on the evidence implicating intestinal bacteria in the pathogenesis of this disorder.
A. ARMUZZI +19 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The mediating role of self-efficacy in the development of entrepreneurial intentions.
Journal of Applied Psychology, 2005 The purpose of this study was to investigate the mediating role of self-efficacy in the development of students' intentions to become entrepreneurs. The authors used structural equation modeling with a sample of 265 master of business administration ...
Hao Zhao, S. Seibert, G. Hills
semanticscholar +1 more source
The effect of assertiveness training on self-efficacy among Iranian high school female students
, 2014 The current study considers the effect of assertiveness on the first-grade high school female students’ self-efficacy. The research method is quasi-experimental and the design is pretest posttest with control group.
Nikoogoftar, Mansooreh +1 more
core
Molecules, 2018 Nintedanib (NDN), a tyrosine kinase inhibitor, has been shown to have anti-tumor, anti-inflammatory, and anti-fibrotic effects in several reports. We investigated the protective effects of NDN against polyhexamethylene guanidine phosphate (PHMG)-induced ...
Hyeon-Young Kim +4 more
doaj +1 more source
, 2023 A fundamental question asked in early survey-based political communication research is whether people feel that their political actions can affect political processes. Research has consistently shown the centrality of this political attitude, known as “political efficacy,” for democratic functioning. In recent research, political communication scholars
openaire +1 more source