Results 141 to 150 of about 8,614,944 (389)
Does socio-economic disadvantage lead to acting out? A reinvigoration of an old question [PDF]
, 2017 Research into socio-economic determinants of school deviance is inconclusive. Recently, scholars argued that economic deprivation, rather than SES background, affects delinquency.
Demanet, Jannick, Van Houtte, Mieke
core
A Method of Preserving Typhoid Stools for Delayed Examination and a Comparative Study of the Efficacy of Eosin Brilliant-Green Agar, Eosin Methylene-Blue Agar, and Endo Agar for the Isolation of Typhoid Bacilli from Stools [PDF]
, 1916 Oscar Teague, A. W. Clurman
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Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Efficacy of Quassia extract on the apple sawfly Hoplocampa testudinea Klug [PDF]
, 2006 The efficacy of Quassia extract with a standardized content of Quassin was proved in various field trials in different regions during three years. The amount of Quassin of 6 g/ha/m tree height will be recommended to practice.
Bathon, H. +5 more
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
THE TREATMENT OF TUBERCULOUS DISEASES: THE EFFICACY OF SODIUM MORRHUATE INJECTIONS COMPARED WITH OTHER TREATMENTS [PDF]
, 1923 P. W. R. Boelke
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Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source