Results 11 to 20 of about 2,837,196 (268)

Efficacy of antidepressants [PDF]

open access: yesBMJ, 2008
In February 2008, Kirsch and colleagues reported a meta-analysis of the efficacy of antidepressants using data from clinical trials submitted to the Food and Drug Administration.1 They provocatively concluded, “there seems little evidence to support the prescription of antidepressant medication to any but the most severely depressed patients.” In ...
Erick H, Turner, Robert, Rosenthal
openaire   +2 more sources

Coaching Efficacy: The Leadership Efficacy Model [PDF]

open access: yes, 2020
This chapter introduces the leadership efficacy model applied to sports coaching. It is proposed in the model that leadership efficacy depends on the congruence between the conceptual cycle of leadership and the practical cycle of leadership and also by considering the leadership styles assumed by coaches and the moderating influence of the antecedent ...
openaire   +2 more sources

Psychotherapy and efficacy [PDF]

open access: yesOrvosi Hetilap, 2015
Evaluation of the efficacy in psychotherapy dates back to the beginnings of psychotherapy itself. However, it is not an easy task to undertake efficacy evaluation because it is expensive and several methodological difficulties may be also present. The authors discuss some questions related efficacy evaluation in psychotherapy, including criteria for ...
Barbara, Papp, Bernadette, Péley
openaire   +2 more sources

Gnetum montanum extract induces apoptosis by inhibiting the activation of AKT in SW480 human colon cancer cells

open access: yesPharmaceutical Biology, 2022
Context Gnetum montanum Markgr. (Gnetaceae) is used to treat rheumatic arthralgia and bruises in the clinic.Objective To exam the activity and mechanism of G.
Xianglong Pan   +10 more
doaj   +1 more source

Effects of Mangifera indica leaves improves blood lipids profile and biochemical indices in high-fat diet-induced hyperlipidaemia rats [PDF]

open access: yesBIO Web of Conferences, 2023
Dyslipidemia a chronic, metabolic syndrome characterized by elevated lipid profiles together with lipid peroxidation in individuals with atherosclerotic cardiovascular disease (CVD).
Liu Lijia   +3 more
doaj   +1 more source

Immune Activity of Polysaccharide Fractions Isolated from Korean Red Ginseng

open access: yesMolecules, 2020
Korean red ginseng (KRG)’s pharmacological efficacy and popular immunomodulatory effects have already been proven in many studies; however, the component of KRG that is effective in immune activity has not been studied before.
Soo Hyun Youn   +5 more
doaj   +1 more source

The Aftermath of Efficacy [PDF]

open access: yesThe Annals of Family Medicine, 2009
As a member of the US Preventive Services Task Force for 12 years and its chair for 5, I have given countless presentations on Task Force recommendations. During questions and comments, clinicians often voice frustration and even hostility to the recommendations because the Task Force does ...
openaire   +2 more sources

Diesel Exhaust Particulates Enhances Susceptibility of LPS-Induced Acute Lung Injury through Upregulation of the IL-17 Cytokine-Derived TGF-β1/Collagen I Expression and Activation of NLRP3 Inflammasome Signaling in Mice

open access: yesBiomolecules, 2021
Diesel exhaust particulates (DEP) adversely affect the respiratory system and exacerbate lung diseases, resulting in high mortality rates. However, its pathogenesis is complicated, and the mechanisms involved are incompletely understood.
Dong Im Kim, Mi-Kyung Song, Kyuhong Lee
doaj   +1 more source

Efficacy of Topiramate [PDF]

open access: yesCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1998
ABSTRACT:In controlled clinical trials, topiramate (TopamaxR) has demonstrated efficacy in refractory patients with complex partial seizures and secondarily generalized tonic-clonic seizures. Approximately 45 percent of 534 patients had a ≥ 50 percent reduction in seizure frequency.
openaire   +2 more sources

miR-1258 Attenuates Tumorigenesis Through Targeting E2F1 to Inhibit PCNA and MMP2 Transcription in Glioblastoma

open access: yesFrontiers in Oncology, 2021
MicroRNAs are a group of endogenous small non-coding RNAs commonly dysregulated in tumorigenesis, including glioblastoma (GBM), the most malignant brain tumor with rapid proliferation, diffuse invasion, and therapeutic resistance.
Hongkun Qin   +8 more
doaj   +1 more source

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