Results 51 to 60 of about 8,716,877 (408)

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. [PDF]

, 2006
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy.
Balkan, S, Checchi, F, Durand, R, Grandesso, F, Guthmann, J P, Hagerman, A, Kamara, S, Lam, E, Scollo, G   +8 more
core   +2 more sources

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

New England Journal of Medicine, 2021
Background Early clinical data from studies of the NVX-CoV2373 vaccine (Novavax), a recombinant nanoparticle vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that contains the full-length spike glycoprotein of the prototype ...
P. Heath, E. Galiza, D. Baxter, M. Boffito, D. Browne, Fiona Burns, D. Chadwick, R. Clark, C. Cosgrove, J. Galloway, A. Goodman, Amardeep Heer, A. Higham, Shalini Iyengar, A. Jamal, Christopher Jeanes, P. Kalra, Christina Kyriakidou, D. McAuley, Agnieszka Meyrick, A. Minassian, J. Minton, P. Moore, Imrozia Munsoor, Helen Nicholls, O. Osanlou, J. Packham, Carol H. Pretswell, Alberto San Francisco Ramos, D. Saralaya, R. Sheridan, Richard Smith, R. Soiza, P. Swift, E. Thomson, J. Turner, M. E. Viljoen, G. Albert, I. Cho, F. Dubovsky, G. Glenn, J. Rivers, A. Robertson, Kathy Smith, S. Toback   +44 more
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The antioxidant activities of Korean Red Ginseng (Panax ginseng) and ginsenosides: A systemic review through in vivo and clinical trials

Journal of Ginseng Research, 2021
A wide range of studies have steadily pointed out the relation of oxidative stress to the primary and secondary causes of human disease and aging. As such, there have been multiple misconceptions about oxidative stress.
Soo Kyung Park, Sun Hee Hyun, Gyo In, Chae-Kyu Park, Yi-Seong Kwak, Young-Jin Jang, Bumseok Kim, Jong-Hoon Kim, Chang-Kyun Han   +8 more
doaj   +1 more source

Evaluation of Antimicrobial Efficacy Against E. Coli Isolates of Different Serogroups Obtained From Diarrhoeic Neonates of Calves, Kids, and Lambs [PDF]

, 2012
Fourteen antimicrobials were evaluated their efficacy against 115 Escherichia coli isolates recovered from faecal samples collected from neonatal diarrhoeic calves (66), kids (25) and lambs (24). Of these isolates 37 were nontypeable, four were of rough
Kataria, A. K. (A), Pachaury, R. (R)
core  

Self-efficacy, religiosity, and crime: profiles of African American youth in urban housing communities [PDF]

, 2017
Youth reporting independently elevated levels of religiosity and self-efficacy tend to abstain from externalizing behavior. However, little is known about the ways in which religiosity and self-efficacy interrelate to impact youth externalizing.
Lombe, Margaret, Nebbitt, Von E., Salas-Wright, Christopher P., Saltzman, Leia Y., Tirmazi, Taqi   +4 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Protective Effects of Cervus elaphus and Eucommia ulmoides Mixture (KGC01CE) on Muscle Loss and Function in Aged Rats

Current Issues in Molecular Biology
Sarcopenia is a condition characterized by a progressive loss of muscle mass and function which are influenced by certain factors such as aging, nutritional deficiencies, and chronic diseases.
Gi-Bang Koo, Han Ol Kwon, Jong Han Kim, Seung Ho Lee, Sung Lye Shim, Kyoung Hwa Jang   +5 more
doaj   +1 more source

Diesel Exhaust Particulates Induce Neutrophilic Lung Inflammation by Modulating Endoplasmic Reticulum Stress-Mediated CXCL1/KC Expression in Alveolar Macrophages

Molecules, 2020
Diesel exhaust particulates (DEP) have adverse effects on the respiratory system. Endoplasmic reticulum (ER) abnormalities contribute to lung inflammation.
Dong Im Kim, Mi-Kyung Song, Hye-In Kim, Kang Min Han, Kyuhong Lee   +4 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source