Results 51 to 60 of about 5,135,675 (370)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Effect of red ginseng NaturalGEL on skin aging
Journal of Ginseng Research, 2020 Background: In aged skin, degradation of collagen fibers, which occupy the majority of the extracellular matrix in the dermis, and changes of aquaporin 3 (AQP3) and skin constituents, such as hyaluronic acid and ceramide, cause wrinkles and decrease skin
Ye Hyang Kim +8 more
doaj
Enhancing efficacy in laser projection by four wavelength combination [PDF]
, 2013 In this letter we present a novel study about the combination of four laser wavelengths in order to maximize both color gamut and efficacy to produce the color white. Firstly, an analytic method to calculate efficacy as function of both four laser wavelegths and four laser powers is derived.
arxiv +1 more source
Dose Selection Balancing Efficacy and Toxicity Using Bayesian Model Averaging [PDF]
arXiv, 2023 Successful pharmaceutical drug development requires finding correct doses that provide an optimum balance between efficacy and toxicity. Competing responses to dose such as efficacy and toxicity often will increase with dose, and it is important to identify a range of doses to provide an acceptable efficacy response (minimum effective dose) while not ...
arxiv
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Marine DrugsIpomoea pes-caprae (L.) Sweet (Convolvulaceae) is a commonly used marine Chinese medicine in the coastal areas of southern China. Traditionally, it has been used in the treatment of rheumatoid arthritis (RA).
Fangfei Zhong +8 more
doaj +1 more source
Molecules, 2020 Currently available toxicity data on humidifier disinfectants are primarily limited to polyhexamethylene guanidine phosphate-induced lung fibrosis.
Mi-Kyung Song, Dong Im Kim, Kyuhong Lee
doaj +1 more source
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Current Issues in Molecular BiologySarcopenia is a condition characterized by a progressive loss of muscle mass and function which are influenced by certain factors such as aging, nutritional deficiencies, and chronic diseases.
Gi-Bang Koo +5 more
doaj +1 more source
Efficacy of Tocilizumab in Patients Hospitalized with Covid-19
New England Journal of Medicine, 2020 Background The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear.
J. Stone +47 more
semanticscholar +1 more source