Results 61 to 70 of about 8,924,877 (409)

Investigating the Mechanism of Action of Ipomoea pes-caprae in the Treatment of Rheumatoid Arthritis Based on Serum Metabolomics and Network Pharmacology

Marine Drugs
Ipomoea pes-caprae (L.) Sweet (Convolvulaceae) is a commonly used marine Chinese medicine in the coastal areas of southern China. Traditionally, it has been used in the treatment of rheumatoid arthritis (RA).
Fangfei Zhong, Siwei Li, Xianglong Pan, Juan Wen, Jinling Xie, Zhengcai Du, Erwei Hao, Jiagang Deng, Xiaotao Hou   +8 more
doaj   +1 more source

The antioxidant activities of Korean Red Ginseng (Panax ginseng) and ginsenosides: A systemic review through in vivo and clinical trials

Journal of Ginseng Research, 2021
A wide range of studies have steadily pointed out the relation of oxidative stress to the primary and secondary causes of human disease and aging. As such, there have been multiple misconceptions about oxidative stress.
Soo Kyung Park, Sun Hee Hyun, Gyo In, Chae-Kyu Park, Yi-Seong Kwak, Young-Jin Jang, Bumseok Kim, Jong-Hoon Kim, Chang-Kyun Han   +8 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Diesel Exhaust Particulates Induce Neutrophilic Lung Inflammation by Modulating Endoplasmic Reticulum Stress-Mediated CXCL1/KC Expression in Alveolar Macrophages

Molecules, 2020
Diesel exhaust particulates (DEP) have adverse effects on the respiratory system. Endoplasmic reticulum (ER) abnormalities contribute to lung inflammation.
Dong Im Kim, Mi-Kyung Song, Hye-In Kim, Kang Min Han, Kyuhong Lee   +4 more
doaj   +1 more source

Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles

Journal of Ginseng Research, 2022
Traditionally, Asian ginseng or Korean ginseng, Panax ginseng has long been used in Korea and China to treat various diseases. The main active components of Panax ginseng is ginsenoside, which is known to have various pharmacological treatment effects ...
Sun Hee Hyun, Kiran D. Bhilare, Gyo In, Chae-Kyu Park, Jong-Hoon Kim   +4 more
doaj   +1 more source

HUBUNGAN ANTARA SELF EFFICACY DENGAN EFEKTIVITAS KOMUNIKASI PADA RECEPTIONIST HOTEL DI MALANG [PDF]

, 2006
Receptionist is a gateway entrance to the hotel guest. Therefore, the effectiveness of communication is a necessary condition that must be owned by the receptionist in carrying out his duties.
Agus Eko Purnomo, Endang Susilowati, Mohammed Ali Wedyan, Rizka Nurfitriani, Syarif Husen   +4 more
core   +1 more source

The Causal Efficacy of Consciousness [PDF]

Entropy, 2020
Mental causation is vitally important to the integrated information theory (IIT), which says consciousness exists since it is causally efficacious. While it might not be directly apparent, metaphysical commitments have consequential entailments concerning the causal efficacy of consciousness.
Matthew Owen, Matthew Owen
openaire   +4 more sources

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction.

New England Journal of Medicine, 2019
BACKGROUND Experimental and clinical evidence support the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medication that is indicated for the treatment of gout and pericarditis.
J. Tardif, S. Kouz, D. Waters, O. Bertrand, R. Diaz, A. Maggioni, F. Pinto, R. Ibrahim, H. Gamra, G. Kiwan, C. Berry, J. López-Sendón, P. Ostadal, W. Koenig, D. Angoulvant, J. Grégoire, M. Lavoie, M. Dubé, D. Rhainds, Mylène Provencher, L. Blondeau, Andreas Orfanos, P. L’allier, M. Guertin, F. Roubille   +24 more
semanticscholar   +1 more source

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine

New England Journal of Medicine, 2021
Background The safety and efficacy of the AZD1222 (ChAdOx1 nCoV-19) vaccine in a large, diverse population at increased risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United States, Chile, and Peru has not been ...
A. Falsey, M. Sobieszczyk, I. Hirsch, Stephanie Sproule, M. Robb, L. Corey, K. Neuzil, William W Hahn, Julie Hunt, M. Mulligan, C. Mcevoy, E. Dejesus, Michael Hassman, S. Little, B. Pahud, A. Durbin, P. Pickrell, E. Daar, L. Bush, Joel Solis, Quito Osuna Carr, Temitope Oyedele, S. Buchbinder, J. Cowden, Sergio L Vargas, Alfredo Guerreros Benavides, R. Call, M. Keefer, B. Kirkpatrick, J. Pullman, T. Tong, Margaret Brewinski Isaacs, David C. Benkeser, H. Janes, M. Nason, Justin A. Green, E. Kelly, Jill Maaske, N. Mueller, Kathryn Shoemaker, Therese Takas, Richard P. Marshall, M. Pangalos, T. Villafana, Antonio Gonzalez-Lopez   +44 more
semanticscholar   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source