Results 41 to 50 of about 2,262,668 (304)

Sufficient Efficiency Criteria for New Classes of Non-Convex Optimization Models

Axioms
In this paper, we introduce and study a new class of minimization models driven by multiple integrals as cost functionals. Concretely, we formulate and establish some sufficient efficiency criteria for a feasible point in the considered optimization ...
Savin Treanţă, Omar Mutab Alsalami
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Risk-based approach to choosing the production asset management strategy for energy company

Известия высших учебных заведений: Проблемы энергетики
RELEVANCE: The possibility of a reasonable choice of an alternative strategy for the organization of maintenance and repair (M&R) of the power company's equipment is a guarantee of the successful implementation of its strategic priorities.
V. M. Levin, N. P. Guzhov, D. A. Boyarova   +2 more
doaj   +1 more source

A Review of the DAC Evaluation Criteria: Upgrading Efficiency

Journal of MultiDisciplinary Evaluation, 2020
Background: Efficiency has remained for long time the Cinderella of evaluation practice. According to several meta-evaluations only a small number of evaluations include robust and meaningful assessments in this field. Purpose: Following the review of
Joaquín de la Concha González
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

ADDITIVES FOR COLD ASPHALT-CONCRETE MADE FROM EMULSION-MINERAL MIXES

Наука и техника, 2015
The article considers the additives use for cold asphalt emulsion mixes. Urgency of the issue consists in the necessity of usage justification and regulation of additive for cold mixes properties adjustment.
P. V. Vavilov, S. E. Kravchenko
doaj  

Electroneurophysiological criteria of efficiency of pathogenetic therapy in diabetic polyneuropathy. [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2016
Purpose: to estimate efficiency of pathogenetic therapy of diabetic polyneuropathy with including of benfotiaminby means of an electroneuromyography.
Lubov Kuzina, Gulnaz Kaishibayeva
doaj   +1 more source

Rapid decay in the relative efficiency of quarantine to halt epidemics in networks

, 2017
Several recent studies have tackled the issue of optimal network immunization by providing efficient criteria to identify key nodes to be removed in order to break apart a network, thus preventing the occurrence of extensive epidemic outbreaks.
Castellano, Claudio, Strona, Giovanni
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source