Results 61 to 70 of about 2,262,668 (304)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Pharmacoeconomics of spastic cerebral palsy
Регуляторные исследования и экспертиза лекарственных средств, 2018 Cerebral palsy (CP) is one of the most widespread and socially significant neurological diseases that affect both various aspects of physical and psychoverbal development of children since birth and stages of their personal development and adaptation in ...
R. I. Yagudina +3 more
doaj
EFFICIENCY CRITERIA FOR LUBRICATING-COOLING FLUIDS
Вестник Северо-Кавказского федерального университета, 2022 There are currently many companies manufacturing a large number of lubricating fluids, which makes it hard for technologists (manufacturers) when trying to make their choice of a lubricating coolant.
Gennady I. Smagin +3 more
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Multi-criteria analysis applied to multi-objective optimal pump scheduling in water systems [PDF]
, 2019 This work presents a multi-criteria-based approach to automatically select specific non-dominated solutions from a Pareto front previously obtained using multi-objective optimization to find optimal solutions for pump control in a water supply system ...
Brentan Bruno +4 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
EFFICIENCY EVALUATION OF APARTMENT HOUSES RECONSTRUCTION WITH OPTIMIZATIONAL CRITERIA APPLICATION
International Journal for Computational Civil and Structural Engineering, 2020 The subject of the study, considered in the article, is the technical condition of the housing stock of the Russian Federation, which is a totality of objects with a characteristic variety of structural and space-planning decisions and increased values ...
Alexander Biryukov +4 more
doaj +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Efficiency Criteria and the Sen-type Social Welfare Function [PDF]
Most of the Social Welfare Functions available in the literature are Paretian, that is increase in anybody's income in the society is welfare augmenting. The Sen type social welfare function possesses this property as well.
Pundarik Mukhopadhaya
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source