Results 151 to 160 of about 1,045,667 (319)
Non-homogeneity in the efficiency evaluation of health systems. [PDF]
BMC Health Serv Res, 2023 Dlouhý M.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2014 The abstract develops some thoughts on the dilemmas - primarily ethical but also theoretical and methodological - that meets the evaluation when it is called upon to make a judgment on social policy interventions specifically targeted to social inclusion
TORRIGIANI, CLAUDIO
core
Evaluation of Water and Sanitation Response for Vulnerable Populations in Lower Juba, Southern Somalia [PDF]
, 2008 The Water and Sanitation Response for Vulnerable Populations in Lower Juba, Southern Somalia' targeted displaced people and those affected by drought, between 1st November 2007 and 31st July 2008.
Githinji, Joseph, Osman, Abdi
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Evaluation of Promoting Food Security Project in the Occupied Palestinian Territories [PDF]
, 2007 The 'Promoting Food Security in the Occupied Palestinian Territories' project was implemented from August 2006 - July 2007. Its principal objective was to contribute to reducing poverty and food insecurity in the OPT, with a focus on decreasing household
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Public Administration Issues, 2008 Evaluation of active market policy is examined using the example of labor market policy. Impact evaluation, the central part of policy evaluation, is focused on cause-and-effect relations between realization of active programs and achieved results. Impact evaluation is done at individual level and provides concrete quantities estimations of program ...
openaire +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source