Results 161 to 170 of about 9,271,499 (307)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A Network Visualization Query System for Multidrug Compatibility Based on a WeChat Mini Program: Preliminary Usability and Efficiency Evaluation. [PDF]

JMIR Form Res
Yang J, Huang X, Wu S, Zhang Y, Zhuang X, Dong Y, Li B, Hong Z.   +7 more
europepmc   +1 more source

Efficiency evaluation and nonlinear multi-objective optimization of forestry industry transformation in the Heilongjiang state-owned forest region. [PDF]

Sci Rep, 2023
Diao S, Geng Y.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Bridging heat-flow and guarded-heater methods for thermoelectric module efficiency evaluation. [PDF]

iScience
Amagai Y, Okawa K, Funahashi R, Yamamoto A, Ohta M.   +4 more
europepmc   +1 more source

Research on the efficiency evaluation of the integration of technology and finance in China's strategic emerging industries. [PDF]

Front Psychol, 2022
Yang Q, Zhao K, Cao L, Wang X, Guo Q, Liu X.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Implementing team-based sequential simulation for medical students in clinical clerkship: preliminary findings and learning efficiency evaluation. [PDF]

BMC Med Educ
Liu HL, Lu PY, Hsu AS, Lin YK, Chan KD, Lee CH, Chang PC.   +6 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Research on the application of refined operating room turnover efficiency in cross-hospital operating room efficiency evaluation. [PDF]

BMC Surg
Zhang C, Gong R, Yan F, Liu Y, Zang L, Pang W, Shu Y.   +6 more
europepmc   +1 more source